Cochrane · systematic review · CD008851
Agomelatine versus other antidepressive agents for major depression
Guaiana, G, Gupta, S, Chiodo, D, et al. · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Common Mental DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
12
current version
GRADE rated
12
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 12 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Agomelatine compared to SSRI for major depression
Population: patients with major depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response rates Number of participants showing a reduction of at least 50% on the Hamilton Depression Rating Scale for Depression, the Montgomery‐Asberg Depression Rating Scale or any other depression scale Agomelatine vs SSRI | RR 1.01 [0.95, 1.08] | 10 studies · 3826 participants | Very low Downgraded: indirectness |
Remission rates The number of participants who achieved remission as defined by: a score of 7 or less on the 17‐item Hamilton Depression Rating Scale; 10 or less on the Montgomery‐Asberg Depression Rating Scale; 'not ill or borderline mentally ill... Agomelatine vs SSRI | RR 0.83 [0.68, 1.01] | 10 studies · 3826 participants | Very low Downgraded: inconsistency, indirectness |
Total drop outs Total number of participants who dropped out during the trial as a proportion of the total number of randomised participants Agomelatine vs SSRI | RR 0.95 [0.83, 1.09] | 10 studies · 3826 participants | Very low Downgraded: indirectness |
Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants Agomelatine vs SSRI | RR 0.99 [0.71, 1.37] | 9 studies · 3377 participants | Very low Downgraded: inconsistency, indirectness |
Drop outs due to side effects Number of participants who dropped out due to side effects during the trial, as a proportion of the total number of randomised participants Agomelatine vs SSRI | RR 0.68 [0.51, 0.91] | 9 studies · 3377 participants | Very low Downgraded: indirectness |
Total number of participants with side effects Total number of participants experiencing at least one side effect Agomelatine vs SSRI | RR 0.91 [0.84, 0.98] | 6 studies · 2490 participants | Very low Downgraded: indirectness |
Agomelatine compared to SNRI for major depression
Population: patients with major depression
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Response rates Number of participants showing a reduction of at least 50% on the Hamilton Depression Rating Scale for Depression, the Montgomery‐Asberg Depression Rating Scale or any other depression scale Agomelatine vs SNRI | RR 1.06 [0.98, 1.16] | 3 studies · 669 participants | Very low Downgraded: indirectness |
Remission rates The number of participants who achieved remission as defined by: a score of 7 or less on the 17‐item Hamilton Depression Rating Scale; 10 or less on the Montgomery‐Asberg Depression Rating Scale; 'not ill or borderline mentally ill... Agomelatine vs SNRI | RR 1.08 [0.94, 1.24] | 3 studies · 669 participants | Very low Downgraded: indirectness |
Total drop outs Total number of participants who dropped out during the trial as a proportion of the total number of randomised participants Agomelatine vs SNRI | RR 0.4 [0.24, 0.67] | 2 studies · 392 participants | Very low Downgraded: indirectness |
Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants Agomelatine vs SNRI | RR 1.01 [0.21, 4.94] | 1 study · 332 participants | Very low Downgraded: indirectness |
Drop outs due to side effects Number of participants who dropped out due to side effects during the trial, as a proportion of the total number of randomised participants Agomelatine vs SNRI | RR 0.3 [0.15, 0.59] | 2 studies · 608 participants | Very low Downgraded: indirectness |
Total number of patients with side effects Total number of participants experiencing at least one side effect Agomelatine vs SNRI | RR 0.72 [0.44, 1.18] | 2 studies · 611 participants | Very low Downgraded: inconsistency, indirectness |