Agomelatine vs SNRIs: Adverse effects (drop‐outs due to adverse effects4)
It is very uncertain whether agomelatine changes drop outs due to side effects Number of participants who dropped out… compared with SNRI (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Agomelatine vs SNRI Drop outs due to side effects Number of participants who dropped out due to side effects during the trial, as a proportion of the total number of randomised participants · patients with major depression It is very uncertain whether agomelatine changes drop outs due to side effects Number of participants who dropped out… compared with SNRI (very low certainty). Agomelatine versus other antidepressive agents for major depression (2013) · Cochrane Headline outcomes only | RR 0.3 [0.15, 0.59] | 2 studies · 608 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Agomelatine versus other antidepressive agents for major depression 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.