Incidence of SAD (modified ITT) · adults with a history of SAD
It is very uncertain whether agomelatine changes incidence of SAD (modified ITT) compared with placebo (very low certainty).
1 finding from 1 review
Adverse events as N of participants with at least one adverse event subjective and objective · adults with a history of SAD
It is very uncertain whether agomelatine changes number of persons with at least one adverse event within a year compared with placebo (very low certainty).
1 finding from 1 review
Severity of depression (SIGH‐SAD score) at the end of the study · adults with a history of SAD
1 finding from 1 review
Quality of life · adults with a history of SAD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of interpersonal and social functioning · adults with a history of SAD
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Number of participants experiencing at least one severe adverse event · adults with a history of SAD
It is very uncertain whether agomelatine changes number of persons with at least one severe adverse event within a year compared with placebo (very low certainty).
1 finding from 1 review
Response rates Number of participants showing a reduction of at least 50% on the Hamilton Depression Rating Scale for Depression, the Montgomery‐Asberg Depression Rating Scale or any other depression scale · patients with major depression
It is very uncertain whether agomelatine changes response rates Number of participants showing a reduction of at… compared with SSRI (very low certainty).
1 finding from 1 review
Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants · patients with major depression
It is very uncertain whether agomelatine changes drop out due to inefficacy Number of participants who dropped out… compared with SNRI (very low certainty).
1 finding from 1 review
Adverse effects (drop‐outs due to adverse effects4) · patients with major depression
It is very uncertain whether agomelatine changes drop outs due to side effects Number of participants who dropped out… compared with SNRI (very low certainty).
1 finding from 1 review
Participants with at least some Side Effects · patients with major depression
It is very uncertain whether agomelatine changes total number of patients with side effects Total number of… compared with SNRI (very low certainty).
1 finding from 1 review
Remission · patients with major depression
It is very uncertain whether agomelatine changes remission rates The number of participants who achieved remission as… compared with SSRI (very low certainty).
1 finding from 1 review
Total drop outs Total number of participants who dropped out during the trial as a proportion of the total number of randomised participants · patients with major depression
It is very uncertain whether agomelatine changes total drop outs Total number of participants who dropped out during… compared with SSRI (very low certainty).
1 finding from 1 review
Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants · patients with major depression
It is very uncertain whether agomelatine changes drop out due to inefficacy Number of participants who dropped out… compared with SSRI (very low certainty).
1 finding from 1 review
Adverse effects (drop‐outs due to adverse effects4) · patients with major depression
It is very uncertain whether agomelatine changes drop outs due to side effects Number of participants who dropped out… compared with SSRI (very low certainty).
1 finding from 1 review
Participants with at least some Side Effects · patients with major depression
It is very uncertain whether agomelatine changes total number of participants with side effects Total number of… compared with SSRI (very low certainty).
1 finding from 1 review
Response rates Number of participants showing a reduction of at least 50% on the Hamilton Depression Rating Scale for Depression, the Montgomery‐Asberg Depression Rating Scale or any other depression scale · patients with major depression
It is very uncertain whether agomelatine changes response rates Number of participants showing a reduction of at… compared with SNRI (very low certainty).
1 finding from 1 review
Remission · patients with major depression
It is very uncertain whether agomelatine changes remission rates The number of participants who achieved remission as… compared with SNRI (very low certainty).
1 finding from 1 review
Total drop outs Total number of participants who dropped out during the trial as a proportion of the total number of randomised participants · patients with major depression
It is very uncertain whether agomelatine changes total drop outs Total number of participants who dropped out during… compared with SNRI (very low certainty).
1 finding from 1 review
Failure to respond at 16‐24 weeks · patients with depression
1 finding from 1 review
Failure to remit at endpoint · patients with depression
Paroxetine showed no clear difference in failure to remit at endpoint HDRS compared with agomelatine (moderate certainty).
1 finding from 1 review