Adverse events of any severity or seriousness · children with respiratory syncytial virus infection
Summary of findings table ‐ Immunoglobulins showed no clear difference in adverse events of any severity or seriousness compared with placebo (low certainty).
1 finding from 1 review
Serious adverse events · children with respiratory syncytial virus infection
Summary of findings table ‐ Immunoglobulins showed no clear difference in serious adverse events compared with placebo (low certainty).
1 finding from 1 review
Effect on later sexual function · symptomatic or early postmenopausal women1.
4 findings from 1 review
no estimate extracted
3 studies · 699 participants
Moderate
no estimate extracted
1 study · 883 participants
Very low
no estimate extracted
1 study · 215 participants
Very low
Show 1 more finding
Effect on later sexual function · Postmenopausal women
5 findings from 1 review
no estimate extracted
1 study · 272 participants
Very low
no estimate extracted
6 studies · 608 participants
Moderate
no estimate extracted
1 study · 104 participants
Very low
Show 2 more findings
Estrogen + progestogens · symptomatic or early postmenopausal women1.
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
ADHD symptoms · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes ADHD symptoms: all parallel‐group trials and first‐period cross‐over… compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Proportion of participants with one or more serious adverse events · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes proportion of participants with one or more serious adverse events compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Adverse events considered non‐serious (penicillin versus doxycycline) · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes proportion of participants with one or more adverse events… compared with placebo or no intervention (very low certainty).
1 finding from 1 review
General behaviour: all parallel‐group trials and first‐period cross‐over trials General behaviour rating scales (Teacher‐rated) · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes general behaviour: all parallel‐group trials and first‐period… compared with placebo or no intervention (very low certainty).
1 finding from 1 review
QoL · Children and adolescents with ADHD
It is very uncertain whether methylphenidate changes quality of life (parent‐rated) compared with placebo or no intervention (very low certainty).
1 finding from 1 review
Seizure freedom · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · people with focal epilepsy
Immunomodulatory interventions probably leads to higher 50% or greater reduction in seizure frequency ‐ ITT analysis compared with placebo (moderate certainty).
1 finding from 1 review
Adverse events of glucocorticoids and immunosuppressive drugs · people with focal epilepsy
Immunomodulatory interventions may leads to higher adverse events of glucocorticoids and immunosuppressive drugs compared with placebo (low certainty).
1 finding from 1 review
Treatment withdrawal · people with focal epilepsy
Immunomodulatory interventions may leads to higher treatment withdrawal compared with placebo (low certainty).
1 finding from 1 review
Allergic reaction · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cognitive effects · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life · people with focal epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
BMD Z score (total hip/femoral neck) · adults with β‐thalassaemia and osteoporosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
BMD Z score (total hip/femoral neck) · children and adults with β‐thalassaemia major and low bone mass
Summary of findings – zinc probably leads to higher BMD Z score (total hip/femoral neck) compared with placebo (moderate certainty).
1 finding from 1 review
BMD Z score (lumbar spine) · children and adults with β‐thalassaemia major and low bone mass
Summary of findings – zinc probably leads to higher BMD Z score (lumbar spine) compared with placebo (moderate certainty).
1 finding from 1 review