Methylphenidate vs placebo or no intervention: Adverse events considered non‐serious (penicillin versus doxycycline)
It is very uncertain whether methylphenidate changes proportion of participants with one or more adverse events… compared with placebo or no intervention (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Methylphenidate vs placebo or no intervention Proportion of participants with one or more adverse events considered non‐serious · children and adolescents (up to and including 18 years of age) with ADHD It is very uncertain whether methylphenidate changes proportion of participants with one or more adverse events… compared with placebo or no intervention (very low certainty). Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD) (2023) · Cochrane Headline outcomes only | RR 1.23 [1.11, 1.37] | 35 studies · 5342 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Methylphenidate for children and adolescents with attention deficit hyperactivity disorder (ADHD) 2023 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.