What do systematic reviews say?

Propionyl‐L‐carnitine vs placebo

The review found no eligible studies for this question.

• Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

RGD peptide matrix vs placebo

The review found no eligible studies for this question.

• Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Solcoseryl vs antiseptic agent

The review found no eligible studies for this question.

• Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Duoderm® (hydroactive dressing) vs antiseptic agent

The review found no eligible studies for this question.

• Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Isoxsuprine vs placebo

The review found no eligible studies for this question.

• Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Ultrasound‐guided injection vs non‐image‐guided injection

• Image‐guided glucocorticoid injection versus injection without image guidance for shoulder pain 2021 · Cochrane Headline outcomes only
  no estimate extracted
  15 studies · 1003 participants
  Moderate

Endometrial injury vs control

Endometrial injury showed no clear difference in live birth per woman randomised (studies at low risk of selection… compared with control (moderate certainty).

• Endometrial injury in women undergoing in vitro fertilisation (IVF) 2021 · Cochrane Headline outcomes only
  OR 1.12 [0.98, 1.28]
  8 studies · 4402 participants
  Moderate

Endometrial injury vs control

Endometrial injury showed no clear difference in miscarriage per woman randomised (studies at low risk of selection… compared with control (moderate certainty).

• Endometrial injury in women undergoing in vitro fertilisation (IVF) 2021 · Cochrane Headline outcomes only
  OR 0.88 [0.68, 1.13]
  8 studies · 4402 participants
  Moderate

Endometrial injury vs control

Endometrial injury showed no clear difference in clinical pregnancy per woman randomised (studies at low risk of… compared with control (moderate certainty).

• Endometrial injury in women undergoing in vitro fertilisation (IVF) 2021 · Cochrane Headline outcomes only
  OR 1.08 [0.95, 1.23]
  8 studies · 4402 participants
  Moderate

Venlafaxine vs no treatment

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 64 participants
  Low

Paroxetine vs doxepin

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 67 participants
  Moderate

Sertraline vs cognitive behavioural therapy

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 117 participants
  Moderate

Sertraline vs cognitive behavioural therapy

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 118 participants
  Moderate

Intervention not reported

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  88 participants
  Low

Selective serotonin reuptake inhibitors vs cognitive behavioural therapy

• Antidepressants for people with epilepsy and depression 2021 · Cochrane Headline outcomes only
  no estimate extracted
  15 participants
  Very low

Repetitive transcranial magnetic stimulation (rTMS) vs control

• Transcranial magnetic stimulation for the treatment of epilepsy 2021 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 109 participants
  Low

Fresh vs frozen embryo transfers

Fresh may leads to lower small for gestational age (birth weight below 10th percentile):… compared with frozen embryo transfers (low certainty).

• Fresh versus frozen embryo transfers in assisted reproduction 2021 · Cochrane Headline outcomes only
  OR 0.36 [0.16, 0.8]
  1 study · 782 participants
  Low

Fresh vs frozen embryo transfers

It is very uncertain whether fresh changes small for gestational age (birth weight below 10th percentile):… compared with frozen embryo transfers (very low certainty).

• Fresh versus frozen embryo transfers in assisted reproduction 2021 · Cochrane Headline outcomes only
  OR 0.82 [0.65, 1.05]
  3 studies · 3940 participants
  Very low

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

iron‐fortified wheat flour with or without other micronutrients added may leads to lower anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with wheat flour (no added iron) with the same other micronutrients added (low certainty).

• Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in… 2021 · Cochrane Headline outcomes only
  RR 0.73 [0.55, 0.97]
  5 studies · 2315 participants
  Low

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

It is very uncertain whether iron‐fortified wheat flour with other micronutrients added changes anaemia (defined as haemoglobin below WHO cut‐off for age and… compared with unfortified wheat flour (no micronutrients added) (very low certainty).

• Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in… 2021 · Cochrane Headline outcomes only
  RR 0.77 [0.41, 1.46]
  2 studies · 317 participants
  Very low