Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

Intervention not reported

New/intensified lipid‐lowering medication · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)

The intervention may leads to higher new/intensified lipid‐lowering medication (low certainty).

1 finding from 1 review

Intervention not reported

New/intensified antihypertensive medication · adults without prevalent cardiovascular disease (primary cardiovascular disease prevention)

The intervention may leads to higher new/intensified antihypertensive medication (low certainty).

1 finding from 1 review

Primary care screening vs secondary care screening

Hypertensive disorders of pregnancy: hypertension · pregnant women, excluding women already diagnosed with GDM in this pregnancy and those with pre‐existing diabetes mellitus

Primary care screening showed no clear difference in hypertensive disorders of pregnancy: hypertension compared with secondary care screening (low certainty).

1 finding from 1 review

Primary care screening vs secondary care screening

Hypertensive disorders of pregnancy: pre‐eclampsia · pregnant women, excluding women already diagnosed with GDM in this pregnancy and those with pre‐existing diabetes mellitus

Primary care screening showed no clear difference in hypertensive disorders of pregnancy: pre‐eclampsia toxemia compared with secondary care screening (low certainty).

1 finding from 1 review

Metformin vs insulin

Hypertensive disorders of pregnancy: pre‐eclampsia · women with type 2 diabetes

It is very uncertain whether maternal outcomes: oral anti‐diabetic agent (metformin) changes hypertensive disorders of pregnancy: pre‐eclampsia compared with insulin (very low certainty).

1 finding from 1 review

Metformin vs insulin

Hypertensive disorders of pregnancy (pregnancy‐induced hypertension) · women with type 2 diabetes

Maternal outcomes: oral anti‐diabetic agent (metformin) may leads to lower hypertensive disorders of pregnancy: pregnancy‐induced hypertension compared with insulin (low certainty).

1 finding from 1 review

Summary of findings: Low‐moderate GI diet vs moderate‐high GI diet (maternal outcomes)

Hypertensive disorders of pregnancy: severe hypertension or pre‐eclampsia · pregnant women with GDM

It is very uncertain whether summary of findings: Low‐moderate GI diet changes hypertensive disorders of pregnancy: severe hypertension or… compared with moderate‐high GI diet (maternal outcomes) (very low certainty).

1 finding from 1 review

Summary of findings: Energy‐restricted diet vs no energy‐restricted diet (maternal outcomes)

Hypertensive disorders of pregnancy: pre‐eclampsia · pregnant women with GDM

Summary of findings: Energy‐restricted diet showed no clear difference in hypertensive disorders of pregnancy: pre‐eclampsia compared with no energy‐restricted diet (maternal outcomes) (low certainty).

1 finding from 1 review