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Evidence found and GRADE certainty

2,890 questions · 3,917 findings · 272 reviews · All outcomes

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No studies found 429 · 11%GRADE not reported 2,657 · 67.8%Very low 512 · 13.1%Low 219 · 5.6%Moderate 80 · 2%High 20 · 0.5%

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

Lactobacilli presence (CFU > 10^5) · Adults undergoing orthodontic treatment

Aligners probably lower the risk of high lactobacilli counts versus fixed appliances in adults at 3 months (RR 0.09, 95% CI 0.02 to 0.47; low certainty).

2 findings from 1 review

Laser fluorescence (DIAGNOdent 2095) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, laser fluorescence (DIAGNOdent 2095) pooled summary ROC AUC was 0.92 for occlusal caries at the dentin detection level; ungraded.

4 findings from 1 review
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Conventional bitewing radiography (D-speed film) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, conventional bitewing radiography (D-speed) pooled sensitivity was 0.79 (95% CI 0.41 to 0.96) for occlusal caries at the dentin detection level; ungraded.

4 findings from 1 review
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Systemic sclerosis (SSc / scleroderma) vs SSc-free individuals (controls)

Periodontitis (prevalence) · Adults (general and hospital populations assessed in case-control studies)

Periodontitis prevalence is significantly higher in systemic sclerosis patients than controls (OR 7.01); certainty ungraded.

1 finding from 1 review

Clear aligners (Invisalign / thermoformed aligners) vs Fixed appliances

S. mutans presence (CFU > 10^5) · Adults undergoing orthodontic treatment

Aligners probably lower the risk of high S. mutans counts versus fixed appliances in adults at 3 months (RR 0.07, 95% CI 0.01 to 0.49; low certainty).

2 findings from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence was lowest in Addis Ababa at 34.20% (95% CI 8.42 to 59.97); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence in the Amhara region was 40.44% (95% CI 24.67 to 56.21); certainty not graded.

1 finding from 1 review

Intervention not reported

Dental caries prevalence · General population in Ethiopia (all ages, age range 6-100 years)

Caries prevalence in other regions (Oromia, Harar, SNNPR) was 42.90% (95% CI 24.68 to 61.12); certainty not graded.

1 finding from 1 review

Visual examination (VE) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the 1/3 dentin caries detection level (Ekstrand; D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, visual examination pooled specificity was 0.77 (95% CI 0.67 to 0.85) for occlusal caries at the 1/3 dentin detection level; ungraded.

4 findings from 1 review
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Conventional bitewing radiography (E-speed film) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the dentin caries detection level (D0-2 versus D3-4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, conventional bitewing radiography (E-speed) pooled diagnostic odds ratio was 127.56 (95% CI 7.38 to 2203.70) for occlusal caries at the dentin detection level; ungraded.

4 findings from 1 review
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Conventional bitewing radiography (D-speed film) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, conventional bitewing radiography (D-speed) pooled sensitivity was 0.65 (95% CI 0.57 to 0.73) for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
Show 1 more finding

Conventional bitewing radiography (E-speed film) vs Cavity preparation or biopsy (operative validation)

Diagnostic accuracy for occlusal caries detection at the caries detection level (D0 versus D1-D4) · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

In in vivo, conventional bitewing radiography (E-speed) pooled sensitivity was 0.80 (95% CI 0.71 to 0.87) for occlusal caries at the caries detection level; ungraded.

4 findings from 1 review
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Quantitative light-induced fluorescence (QLF) vs Histological validation (in vitro) or cavity preparation/biopsy (in vivo)

Occlusal caries detection accuracy · Human permanent posterior teeth (premolars and molars) in patients, occlusal (pit-and-fissure) surfaces

No eligible QLF studies met the meta-analysis inclusion criteria (candidate QLF studies were identified but none had acceptable index/reference tests and reporting quality).

1 finding from 1 review