Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,815 questions · 6,211 findings · 638 reviews · Headline outcomes only

No studies found 1,052 · 16.9%GRADE not reported 441 · 7.1%Very low 1,700 · 27.4%Low 1,651 · 26.6%Moderate 1,070 · 17.2%High 297 · 4.8%

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Intervention not reported

Morbidity (metabolic syndrome)d · children and adolescents with obesity

It is very uncertain whether the intervention changes morbidity (metabolic syndrome)d (very low certainty).

1 finding from 1 review

Upper limb exercise training vs control (no intervention/usual care/isotonic exercise)

Vascular access complications · CKD patients who underwent AVF creation

It is very uncertain whether upper limb exercise training changes vascular access complications (isometric versus isotonic exercise… compared with control (no intervention/usual care/isotonic exercise) (very low certainty).

1 finding from 1 review

Upper limb exercise training vs control (no intervention/usual care/isotonic exercise)

Ultrasound maturation (isometric versus isotonic exercise training) · CKD patients who underwent AVF creation

Upper limb exercise training may leads to higher ultrasound maturation (isometric versus isotonic exercise training) compared with control (no intervention/usual care/isotonic exercise) (low certainty).

1 finding from 1 review

Upper limb exercise training vs control (no intervention/usual care/isotonic exercise)

Clinical maturation (isometric versus isotonic exercise training) · CKD patients who underwent AVF creation

Upper limb exercise training may leads to higher clinical maturation (isometric versus isotonic exercise training) compared with control (no intervention/usual care/isotonic exercise) (low certainty).

1 finding from 1 review

Dexrazoxane vs no cardioprotective intervention

Tumour response rate Defined as number of complete responses (i.e. disappearance of active Hodgkin lymphoma (gallium negative, ≥ 70% decrease in the sum of the products of the perpendicular diameters of measurable lesions, and negative bone marrow... · children with cancer receiving anthracyclines

Dexrazoxane showed no clear difference in tumour response rate Defined as number of complete responses (i.e.… compared with no cardioprotective intervention (low certainty).

1 finding from 1 review

Foam sclerotherapy vs foam sclerotherapy

Cosmetic appearance · participants with varicose veinsa

It is very uncertain whether foam sclerotherapy changes cosmetic appearance (self‐described cosmetic improvement) compared with foam sclerotherapy (very low certainty).

1 finding from 1 review