Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,092 questions · 3,199 findings · 339 reviews · Headline outcomes only

No studies found 714 · 22.3%GRADE not reported 181 · 5.7%Very low 695 · 21.7%Low 908 · 28.4%Moderate 568 · 17.8%High 133 · 4.2%

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 800 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (moderate certainty).

1 finding from 1 review

Oral aciclovir (short‐term) vs placebo

Adverse effects during use of the preventative intervention ‐ aciclovir 400 mg twice daily · participants with recurrent herpes labialis

Oral aciclovir (short‐term) showed no clear difference in adverse effects during use of the preventative intervention ‐… compared with placebo (low certainty).

1 finding from 1 review

Oral nutritional supplements vs usual care or control

Infectious complications · people undergoing gastrointestinal surgery

It is very uncertain whether oral nutritional supplements changes infectious complications recorded up to 30 days postdischarge compared with usual care or control (very low certainty).

1 finding from 1 review

Oral nutritional supplements vs multivitamin and mineral supplement

Complications · Partcipants with bladder cancer undergoing radical cystectomy (male n = 314, female n = 87; age (interquartile range) 59 to 74)Country:…

Oral nutritional supplements showed no clear difference in complications compared with multivitamin and mineral supplement (low certainty).

1 finding from 1 review

Oral nutritional supplements vs multivitamin and mineral supplement

All‐cause mortality · Partcipants with bladder cancer undergoing radical cystectomy (male n = 314, female n = 87; age (interquartile range) 59 to 74)Country:…

Oral nutritional supplements showed no clear difference in mortality compared with multivitamin and mineral supplement (low certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of admission during ED stay · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) probably leads to lower rate of admission during ED stay compared with placebo (moderate certainty).

1 finding from 1 review

Oral ondansetron (weight based) vs placebo

Rate of admission 72 hrs · patients with vomiting related to acute gastroenteritis with mild to moderate dehydration

Oral ondansetron (weight based) showed no clear difference in rate of admission 72 hrs compared with placebo (low certainty).

2 findings from 1 review