Cochrane · systematic review · CD008300
Treating BCG‐induced disease in children
Cuello‐García, CA, Pérez‐Gaxiola, G, Jiménez Gutiérrez, C · Cochrane Database of Systematic Reviews · 2013 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 60%Low 2 · 40%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Oral Isoniazid (INH) versus no intervention for BCG adverse reactions
Population: patients with BCG adverse reactions1
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical failure clinical observation Oral Isoniazid (INH) vs no intervention | RR 1.48 [0.79, 2.78] | 2 studies · 54 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Oral erythromycin versus placebo or no intervention for BCG adverse reactions
Population: patients with BCG adverse reactions
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical failure clinical observation Oral erythromycin vs placebo or no intervention | RR 1.03 [0.7, 1.53] | 3 studies · 148 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Oral isoniazid plus rifampicin versus no intervention for BCG vaccine adverse reactions
Population: infants with BCG vaccine adverse reactions1
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical failure clinical observation Oral isoniazid plus rifampicin vs no intervention | RR 1.2 [0.51, 2.83] | 1 study · 35 participants | Very low Downgraded: risk of bias |
Needle aspiration versus no intervention for BCG vaccine adverse reactions
Population: infants with BCG vaccine adverse reactions1
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Clinical failure No regression of abscess by clinical evaluation2 Needle aspiration vs no intervention | RR 0.13 [0.03, 0.55] | 1 study · 77 participants | Low Downgraded: risk of bias |
Local instillation of isoniazid versus erythromycin for BCG adverse reactions
Population: patients with BCG adverse reactions1
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Time to resolution of illness Clinical observation Local instillation of isoniazid vs erythromycin | no estimate extracted | 1 study · 27 participants | Low Downgraded: risk of bias |