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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.
75,239 questions in 5,342 reviews
current versionsNo studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
nHFV vs nIPPV used Death or chronic lung disease · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs nIPPV used Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 1 study · 36 participants | Very low |
nHFV vs nIPPV used Neurodevelopmental disability · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs HFNC Mortality before hospital discharge · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 1 study · 37 participants | Very low |
nHFV vs invasive respiratory therapy Endotracheal intubation or reintubation To discharge · preterm infants with respiratory distress Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs HFNC Endotracheal intubation or reintubation To discharge · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 2.94 [0.65, 13.27] | 1 study · 37 participants | Very low |
nHFV vs HFNC Chronic lung disease · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 1.18 [0.46, 2.98] | 1 study · 37 participants | Very low |
nHFV vs HFNC Death or chronic lung disease · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs HFNC Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 1 study · 37 participants | Very low |
nHFV vs HFNC Neurodevelopmental disability · preterm infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs nCPAP Mortality before hospital discharge · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.92 [0.52, 1.64] | 6 studies · 1427 participants | Moderate |
nHFV vs nCPAP Endotracheal reintubation To discharge · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.42 [0.35, 0.51] | 11 studies · 1897 participants | Low |
nHFV vs nCPAP Chronic lung disease · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.78 [0.67, 0.91] | 10 studies · 1829 participants | Low |
nHFV vs nCPAP Death or chronic lung disease · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.9 [0.77, 1.06] | 2 studies · 966 participants | Moderate |
nHFV vs nCPAP Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.8 [0.57, 1.13] | 3 studies · 1117 participants | Moderate |
nHFV vs invasive respiratory therapy Chronic lung disease · preterm infants with respiratory distress Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.38 [0.09, 1.59] | 2 studies · 180 participants | Very low |
nHFV vs nCPAP Neurodevelopmental disability · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.92 [0.37, 2.29] | 1 study · 74 participants | Very low |
nHFV vs nIPPV Mortality before hospital discharge · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 1.83 [0.7, 4.79] | 2 studies · 984 participants | Low |
nHFV vs nIPPV Endotracheal reintubation To discharge · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.69 [0.54, 0.89] | 6 studies · 1364 participants | Moderate |
nHFV vs nIPPV Chronic lung disease · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.88 [0.75, 1.04] | 4 studies · 1236 participants | Moderate |
nHFV vs nIPPV Death or chronic lung disease · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.92 [0.79, 1.08] | 3 studies · 1070 participants | Moderate |
nHFV vs nIPPV Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.78 [0.55, 1.1] | 4 studies · 1162 participants | Moderate |
nHFV vs nIPPV Neurodevelopmental disability · ventilated preterm infants with planned extubation Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.88 [0.35, 2.16] | 1 study · 72 participants | Low |
nHFV vs nIPPV following failure of initial non‐invasive respiratory support Mortality before hospital discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 1.44 [0.1, 21.33] | 1 study · 39 participants | Low |
nHFV vs nIPPV following failure of initial non‐invasive respiratory support Endotracheal intubation To discharge · ventilated preterm infants with failure of initial non‐invasive respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 1.23 [0.51, 2.98] | 1 study · 39 participants | Very low |
nHFV vs nIPPV following failure of initial non‐invasive respiratory support Chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 1.01 [0.7, 1.47] | 1 study · 39 participants | Low |
nHFV vs invasive respiratory therapy Death or chronic lung disease · preterm infants with respiratory distress Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs nIPPV following failure of initial non‐invasive respiratory support Death or chronic lung disease · ventilated preterm infants with failure of initial non‐invasive respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs nIPPV following failure of initial non‐invasive respiratory support Intraventricular haemorrhage, Papile grade 3/4 · ventilated preterm infants with failure of initial non‐invasive respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.47 [0.02, 10.87] | 1 study · 39 participants | Low |
nHFV vs nIPPV following failure of initial non‐invasive respiratory support Neurodevelopmental disability · ventilated preterm infants with failure of initial non‐invasive respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs invasive respiratory therapy Intraventricular haemorrhage, Papile grade 3/4 · preterm infants with respiratory distress Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs invasive respiratory therapy Neurodevelopmental disability · preterm infants with respiratory distress Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | no estimate extracted | 0 studies · 0 participants | Ungraded |
nHFV vs nCPAP used Mortality before hospital discharge · newborn (term* and preterm) infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 1 [0.41, 2.41] | 4 studies · 531 participants | Very low |
nHFV vs nCPAP used Endotracheal intubation To discharge · newborn (term* and preterm) infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 0.52 [0.33, 0.82] | 5 studies · 571 participants | Low |
nHFV vs nCPAP used Chronic lung disease · newborn (term* and preterm) infants with respiratory distress for initial respiratory support Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane | RR 1.35 [0.8, 2.27] | 4 studies · 481 participants | Low |
Alpha‐lipoic acid vs placebo Change in neuropathy symptoms · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane | no estimate extracted | 1 study · 330 participants | Moderate |
Alpha‐lipoic acid vs placebo Change in impairment · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane | no estimate extracted | 1 study · 245 participants | Low |
Alpha‐lipoic acid vs placebo Change in any validated quality of life score · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane | no estimate extracted | NR | No studies |
Alpha‐lipoic acid vs placebo Complications of DPN · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane | no estimate extracted | NR | No studies |
Alpha‐lipoic acid vs placebo Adverse events leading to cessation of treatment · people with DPN Alpha‐lipoic acid for diabetic peripheral neuropathy (2024) · Cochrane | RR 1.48 [0.5, 4.35] | 3 studies · 1090 participants | Moderate |
Standard polyurethane plus tissue adhesive vs standard polyurethane Arterial catheter failure assessed during catheter dwell · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 0.44 [0.2, 0.98] | 2 studies · 165 participants | Very low |
Bordered polyurethane vs standard polyurethane Adverse events assessed during catheter dwell · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 0.33 [0.01, 7.87] | 1 study · 60 participants | Very low |
Standard polyurethane plus sutureless securement devices vs standard polyurethane Arterial catheter failureassessed during catheter dwell · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 0.78 [0.4, 1.52] | 2 studies · 157 participants | Very low |
Standard polyurethane plus sutureless securement devices vs standard polyurethane Incidence of catheter‐related bloodstream infection assessed during catheter dwell or 48 hours after removal · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | no estimate extracted | 2 studies · 157 participants | Very low |
Standard polyurethane plus sutureless securement devices vs standard polyurethane Dislodgement assessed during catheter dwell · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 0.14 [0.01, 2.57] | 2 studies · 157 participants | Very low |
Standard polyurethane plus sutureless securement devices vs standard polyurethane Occlusion assessed during catheter dwell · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 1.94 [0.5, 7.48] | 2 studies · 157 participants | Very low |
Standard polyurethane plus sutureless securement devices vs standard polyurethane Adverse events assessed during catheter dwell and on product removal · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 1.94 [0.19, 20.24] | 2 studies · 157 participants | Very low |
Integrated securement dressings vs standard polyurethane Arterial catheter failureassessed during catheter dwell or 48 hours after removal · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 1.96 [0.8, 4.84] | 1 study · 105 participants | Low |
Integrated securement dressings vs standard polyurethane Incidence of catheter‐related bloodstream infectionassessed during catheter dwell or 48 hours after removal · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | no estimate extracted | 1 study · 105 participants | Low |
Integrated securement dressings vs standard polyurethane Dislodgement assessed during catheter dwell · people with arterial catheter dressing and securement Dressings and securement devices to prevent complications for peripheral arterial catheters (2024) · Cochrane | RR 0.33 [0.04, 3.04] | 1 study · 105 participants | Low |