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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Every word you type has to appear somewhere in the question, and the closest matches are ranked first.

Limit to evidence status or GRADE (optional)

75,239 questions in 5,342 reviews

current versions
No studies 15,213 · 20.2%Ungraded 10,323 · 13.7%Very low 17,528 · 23.3%Low 17,951 · 23.9%Moderate 11,190 · 14.9%High 3,034 · 4%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Mindfulness‐enhanced parent training vs no‐treatment, waitlist, or attentional control
Parenting stress; postintervention · parents of children between the ages of 0 and 18 years
Mindfulness‐enhanced parenting programmes for improving the psychosocial outcomes of children (0 to 18… (2024) · Cochrane
no estimate extracted2 studies · 112 participantsVery low
Mindfulness‐enhanced parent training vs no‐treatment, waitlist, or attentional control
Parent mindfulness; postintervention · parents of children between the ages of 0 and 18 years
Mindfulness‐enhanced parenting programmes for improving the psychosocial outcomes of children (0 to 18… (2024) · Cochrane
no estimate extracted3 studies · 515 participantsVery low
Mindfulness‐enhanced parent training vs no‐treatment, waitlist, or attentional control
Measures of self‐compassion · parents of children between the ages of 0 and 18 years
Mindfulness‐enhanced parenting programmes for improving the psychosocial outcomes of children (0 to 18… (2024) · Cochrane
no estimate extractedNRNo studies
Mindfulness‐enhanced parent training vs parent training
Child emotional and behavioural adjustment; postintervention · parents of children between the ages of 0 and 18 years
Mindfulness‐enhanced parenting programmes for improving the psychosocial outcomes of children (0 to 18… (2024) · Cochrane
no estimate extracted5 studies · 203 participantsVery low
Mindfulness‐enhanced parent training vs parent training
Adverse effects · parents of children between the ages of 0 and 18 years
Mindfulness‐enhanced parenting programmes for improving the psychosocial outcomes of children (0 to 18… (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
All‐cause mortality · participants with gallstone disease (cholesterol, pigment, or mixed)
Modified dietary fat intake for treatment of gallstone disease in people of any age (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Serious adverse events at longest · participants with gallstone disease (cholesterol, pigment, or mixed)
Modified dietary fat intake for treatment of gallstone disease in people of any age (2024) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Health‐related quality of life · participants with gallstone disease (cholesterol, pigment, or mixed)
Modified dietary fat intake for treatment of gallstone disease in people of any age (2024) · Cochrane
no estimate extractedNRNo studies
Infliximab vs placebo
Clinical relapse (at 30‐32 weeks, CDAI > 150) · patients with Crohn's disease (mixed disease activity population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.73 [0.63, 0.84]2 studies · 408 participantsModerate
Infliximab vs purine analogues
Loss of clinical response · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
no estimate extractedNRNo studies
Infliximab vs purine analogues
Withdrawal due to adverse events · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
no estimate extractedNRNo studies
Infliximab vs purine analogues
Serious adverse events (at 2 years) · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.79 [0.37, 1.68]1 study · 140 participantsVery low
Infliximab vs biosimilar
Clinical relapse (at 52 weeks, HBI > 4) · patients with Crohn's disease (with mixed/low disease activity at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 1.18 [0.82, 1.69]1 study · 155 participantsLow
Infliximab vs biosimilar
Loss of clinical response (at 52 weeks, HBI change from baseline of less than 4 points and a total score of less than 7 points) · patients with Crohn's disease (with mixed/low disease activity at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 1.5 [1.01, 2.23]1 study · 155 participantsLow
Infliximab vs biosimilar
Withdrawal due to adverse events (at 52 weeks) · patients with Crohn's disease (with mixed/low disease activity at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 20.73 [2.86, 150.33]1 study · 155 participantsLow
Infliximab vs biosimilar
Serious adverse events (at 52 weeks) · patients with Crohn's disease (with mixed/low disease activity at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.99 [0.39, 2.5]1 study · 155 participantsLow
Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues
Clinical relapse (at 22 weeks, CDAI > 150) · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 1.01 [0.65, 1.57]1 study · 53 participantsVery low
Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues
Loss of clinical response (at 22 weeks, less than 100 points in CDAI change) · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.94 [0.7, 1.25]1 study · 53 participantsVery low
Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues
Withdrawal due to adverse events (at 30 weeks) · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.77 [0.3, 1.97]1 study · 53 participantsVery low
Infliximab vs placebo
Loss of clinical response (at 32 weeks, less than 70 points in CDAI change) · patients with Crohn's disease (mixed disease activity population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.59 [0.37, 0.96]1 study · 73 participantsVery low
Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues
Serious adverse events · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
no estimate extractedNRNo studies
Infliximab vs adalimumab
Clinical relapse · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
no estimate extractedNRNo studies
Infliximab vs adalimumab
Loss of clinical response (at 56 weeks, less than 100 points in CDAI change) · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.68 [0.29, 1.59]1 study · 73 participantsVery low
Infliximab vs adalimumab
Withdrawal due to adverse events (at 56 weeks) · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.1 [0.01, 0.72]1 study · 73 participantsVery low
Infliximab vs adalimumab
Serious adverse events (at 56 weeks) · patients with Crohn's disease (active disease population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.09 [0.01, 1.54]1 study · 73 participantsVery low
Infliximab vs placebo
Withdrawal due to adverse events (at 32‐54 weeks) · patients with Crohn's disease (mixed disease activity population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.66 [0.37, 1.19]2 studies · 355 participantsVery low
Infliximab vs placebo
Serious adverse events (at 54 weeks) · patients with Crohn's disease (mixed disease activity population with clinical response at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.6 [0.36, 1]1 study · 282 participantsVery low
Infliximab combined with purine analogues vs purine analogues
Clinical relapse (at 48 weeks, CDAI of 150 or greater together with an increase in CDAImore than 70 points above baseline over 2 consecutive weeks or definitive clinical relapse requiring immediate intervention, as judged by the treating physician) · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.2 [0.1, 0.42]1 study · 115 participantsModerate
Infliximab combined with purine analogues vs purine analogues
Loss of clinical response · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
no estimate extractedNRNo studies
Infliximab combined with purine analogues vs purine analogues
Withdrawal due to adverse events (at 48 weeks) · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 0.47 [0.15, 1.49]1 study · 115 participantsVery low
Infliximab combined with purine analogues vs purine analogues
Serious adverse events (at 48 weeks to 2 years) · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
RR 1.19 [0.54, 2.64]2 studies · 257 participantsVery low
Infliximab vs purine analogues
Clinical relapse · Crohn's disease patients (in remission at baseline)
Infliximab for maintenance of medically‐induced remission in Crohn's disease (2024) · Cochrane
no estimate extractedNRNo studies
ORT‐based algorithm vs standard starting dose of FSH
Live birth or ongoing pregnancy · women undergoing IVF/ICSI
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 1.12 [0.98, 1.29]7 studies · 4400 participantsLow
Anticipated normal responders: higher vs lower dose of FSH
IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
no estimate extracted1 study · 37 participantsUngraded
Anticipated high responders: higher vs lower dose of FSH
IU vs 100 IU · women undergoing IVF/ICSI who are anticipated to have a hyper‐response to stimulation based on at least one ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 0.98 [0.66, 1.46]1 study · 521 participantsLow
ORT‐based algorithm vs standard starting dose of FSH
OHSS · women undergoing IVF/ICSI
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 0.74 [0.42, 1.28]5 studies · 2724 participantsLow
ORT‐based algorithm vs standard starting dose of FSH
Clinical pregnancy · women undergoing IVF/ICSI
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 1.04 [0.91, 1.18]7 studies · 4400 participantsLow
Anticipated low responders: higher vs lower dose of FSH
300/450 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a low response to stimulation based on one or more ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 1.2 [0.78, 1.86]3 studies · 538 participantsLow
Anticipated low responders: higher vs lower dose of FSH
400/450 IU vs 300 IU · women undergoing IVF/ICSI who are anticipated to have a low response to stimulation based on one or more ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 0.77 [0.19, 3.19]1 study · 62 participantsLow
Anticipated low responders: higher vs lower dose of FSH
IU vs 450 IU · women undergoing IVF/ICSI who are anticipated to have a low response to stimulation based on one or more ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 1.33 [0.71, 2.52]1 study · 356 participantsLow
Anticipated normal responders: higher vs lower dose of FSH
IU vs 100 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 0.88 [0.57, 1.36]2 studies · 522 participantsLow
Anticipated normal responders: higher vs lower dose of FSH
225/200 IU vs 150 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 0.98 [0.7, 1.36]2 studies · 686 participantsLow
Anticipated normal responders: higher vs lower dose of FSH
IU vs 225 IU · women undergoing IVF/ICSI who are anticipated to have a normal response to stimulation based on at least one ORT measure
Individualised gonadotropin dose selection using markers of ovarian reserve for women undergoing in vitro… (2024) · Cochrane
OR 0.65 [0.32, 1.32]1 study · 135 participantsLow
nHFV vs invasive respiratory therapy
Mortality before hospital discharge · preterm infants with respiratory distress
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane
RR 0.67 [0.2, 2.18]1 study · 80 participantsVery low
nHFV vs nCPAP used
Death or chronic lung disease · newborn (term* and preterm) infants with respiratory distress for initial respiratory support
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane
RR 2.5 [0.52, 12.01]1 study · 68 participantsLow
nHFV vs nCPAP used
Intraventricular haemorrhage, Papile grade 3/4 · newborn (term* and preterm) infants with respiratory distress for initial respiratory support
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane
RR 1.17 [0.36, 3.78]4 studies · 531 participantsLow
nHFV vs nCPAP used
Neurodevelopmental disability · newborn (term* and preterm) infants with respiratory distress for initial respiratory support
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane
no estimate extracted0 studies · 0 participantsUngraded
nHFV vs nIPPV used
Mortality before hospital discharge · preterm infants with respiratory distress for initial respiratory support
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane
RR 1.86 [0.9, 3.83]2 studies · 84 participantsLow
nHFV vs nIPPV used
Endotracheal intubation To discharge · preterm infants with respiratory distress for initial respiratory support
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane
RR 1.33 [0.76, 2.34]5 studies · 228 participantsLow
nHFV vs nIPPV used
Chronic lung disease · preterm infants with respiratory distress for initial respiratory support
Non‐invasive high‐frequency ventilation in newborn infants with respiratory distress (2024) · Cochrane
RR 0.63 [0.42, 0.95]5 studies · 307 participantsLow