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Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,645 questions in 107 reviews · Wounds
current versionsNo studies 651 · 39.6%Ungraded 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure Wound infection · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 0.44 [0.16, 1.17] | 6 studies · 559 participants | Very low |
Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure Wound dehiscence · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 0.82 [0.17, 3.84] | 3 studies · 250 participants | Very low |
Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure Time to return to work · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | 1 study · 60 participants | Low |
Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure Quality of life ‐ not reported · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap) Time to wound healing · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | 6 studies · 526 participants | Moderate |
Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap) Proportion of wounds healed · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 1.2 [0.77, 1.86] | 1 study · 30 participants | Low |
Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap) Recurrence rate · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 1.14 [0.61, 2.14] | 9 studies · 890 participants | Low |
Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap) Wound infection · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 1.55 [0.9, 2.68] | 8 studies · 869 participants | Low |
Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap) Wound dehiscence · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 1.2 [0.41, 3.5] | 7 studies · 776 participants | Low |
Summary of findings table ‐ Off‐midline closure vs conventional midline closure Proportion of wounds healed · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 1.13 [0.92, 1.39] | 2 studies · 207 participants | Very low |
Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap) Time to return to work · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | 6 studies · 541 participants | Low |
Summary of findings table ‐ Off‐midline closure (Karydakis flap) vs off‐midline closure (Limberg flap) Quality of life ‐ not reported · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Off‐midline closure vs conventional midline closure Recurrence rate · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 0.22 [0.11, 0.45] | 13 studies · 1492 participants | Moderate |
Summary of findings table ‐ Off‐midline closure vs conventional midline closure Wound infection · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 0.32 [0.22, 0.49] | 13 studies · 1568 participants | Moderate |
Summary of findings table ‐ Off‐midline closure vs conventional midline closure Wound dehiscence · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 0.44 [0.27, 0.71] | 11 studies · 1389 participants | Low |
Summary of findings table ‐ Off‐midline closure vs conventional midline closure Time to return to work · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | 6 studies · 820 participants | Low |
Summary of findings table ‐ Off‐midline closure vs conventional midline closure Quality of life ‐ not reported · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure Time to wound healing · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | no estimate extracted | 1 study · 116 participants | Low |
Summary of findings table ‐ Off‐midline closure vs tension‐free midline closure Proportion of wounds healed · pilonidal sinus Midline and off‐midline wound closure methods after surgical treatment for pilonidal sinus (2024) · Cochrane | RR 1.24 [1.06, 1.46] | 1 study · 115 participants | Low |
Summary of findings: endovenous ablation and compression vs compression alone Ulcer healing time (measured as days from randomisation and followed‐up to 1 year) · adults with venous leg ulcers. Endovenous ablation for venous leg ulcers (2023) · Cochrane | HR 1.41 [1.36, 1.47] | 2 studies · 466 participants | High |
Summary of findings: endovenous ablation and compression vs compression alone Proportion of ulcers healed at 90 days (90 days · adults with venous leg ulcers. Endovenous ablation for venous leg ulcers (2023) · Cochrane | RR 1.14 [1, 1.3] | 2 studies · 466 participants | Moderate |
Summary of findings: endovenous ablation and compression vs compression alone Proportion of ulcers healed at one year (52 week · adults with venous leg ulcers. Endovenous ablation for venous leg ulcers (2023) · Cochrane | RR 1.08 [1.02, 1.14] | 2 studies · 505 participants | Moderate |
Summary of findings: endovenous ablation and compression vs compression alone Ulcer recurrence (1 year · adults with venous leg ulcers. Endovenous ablation for venous leg ulcers (2023) · Cochrane | RR 0.29 [0.03, 2.48] | 2 studies · 460 participants | Low |
Summary of findings: endovenous ablation and compression vs compression alone Ulcer‐free time (measured as days from healing of index ulcer to recurrence) · adults with venous leg ulcers. Endovenous ablation for venous leg ulcers (2023) · Cochrane | no estimate extracted | 1 study · 450 participants | Low |
NPWT vs standard dressings therapy The proportion of pressure ulcers healed · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT vs the Healthpoint system Adverse events  · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT combined with internet‐plus home care vs standard care Outcomes  · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT combined with internet‐plus home care vs standard care The proportion of pressure ulcers healed · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | 1 study · 60 participants | Ungraded |
NPWT combined with internet‐plus home care vs standard care Time to complete wound healing · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT combined with internet‐plus home care vs standard care Adverse events  · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT vs standard dressings therapy Time to complete wound healing · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT vs standard dressings therapy Adverse events · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | RR 1.25 [0.64, 2.44] | 1 study · 12 participants | Very low |
NPWT vs moist wound healing The proportion of pressure ulcers healed · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT vs moist wound healing Time to complete wound healing · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT vs moist wound healing Adverse events  · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT vs the Healthpoint system Outcomes  · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
NPWT vs the Healthpoint system The proportion of pressure ulcers healed · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | 1 study · 28 participants | Ungraded |
NPWT vs the Healthpoint system Time to complete wound healing · adults with pressure ulcers Negative pressure wound therapy for treating pressure ulcers (2023) · Cochrane | no estimate extracted | NR | No studies |
Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor Complete ulcer healing · pressure ulcer Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 1.17 [0.58, 2.35] | 1 study · 65 participants | Very low |
Lysine hyaluronate vs sodium hyaluronate Health‐related quality of life ‐ not reported · people with pressure ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Lysine hyaluronate vs sodium hyaluronate Pain · people with pressure ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Lysine hyaluronate vs sodium hyaluronate Change in ulcer size · people with pressure ulcers Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 1 study · 10 participants | Very low |
Hyaluronic acid vs lyophilised collagen Complete ulcer healing · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | 1 study · 20 participants | Ungraded |
Hyaluronic acid vs lyophilised collagen Time to complete healing · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | MD 16.6 | 1 study · 20 participants | Very low |
Hyaluronic acid vs lyophilised collagen Adverse events ‐ not reported · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs lyophilised collagen Health‐related quality of life ‐ not reported · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs lyophilised collagen Pain · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | Very low |
Hyaluronic acid vs lyophilised collagen Change in ulcer size · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |
Hyaluronic acid vs conventional dressing (sterile petrolatum gauze) Complete ulcer healing (12 weeks ‐ 84 days) · foot ulcers in people with diabetes Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | RR 2.2 [0.97, 4.97] | 1 study · 34 participants | Very low |
Platelet‐rich growth factor + hyaluronic acid vs platelet‐rich growth factor Time to complete wound healing ‐ not reported · pressure ulcer Dressings and topical agents containing hyaluronic acid for chronic wound healing (2023) · Cochrane | no estimate extracted | NR | No studies |