Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

221 questions · 229 findings · 44 reviews

No studies found 34 · 14.8%GRADE not reported 86 · 37.6%Very low 57 · 24.9%Low 38 · 16.6%Moderate 9 · 3.9%High 5 · 2.2%

4% articaine, 1:100,000 epinephrine vs 2% lidocaine, 1:100,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

4% articaine, 1:100,000 epinephrine may leads to higher duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (low certainty).

1 finding from 1 review

4% articaine, 1:200,000 epinephrine vs 0.5% bupivacaine, 1:200,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 4% articaine, 1:200,000 epinephrine changes duration of anaesthesia (soft tissue, simulated) compared with 0.5% bupivacaine, 1:200,000 epinephrine (very low certainty).

1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less
1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Powered toothbrush (any mode of action) vs Manual toothbrush

Adverse events (soft tissue trauma) · Individuals of any age with no reported disability that might affect toothbrushing (including people wearing orthodontic appliances)
1 finding from 1 review
  • SoF 'Adverse events' row (narrative): There was no apparent relationship between the use of powered toothbrushes and soft tissue trauma. In part this finding was due to the very small number of adverse events reported…
    40 studies
    GRADE not reported

Individually designed, patient-centred preventive programme: dietary counselling (snacking timing, regular meals, fermentable carbohydrates) plus toothbrushing counselling, delivered by trained dental hygienists (a multi-intervention) vs Basic prevention offered as standard in public dental clinics

Drinking soft drinks less than daily · Children aged 11 to 12 years with at least one active initial caries lesion, screened in a town in Finland
1 finding from 1 review

Er:YAG laser surface debridement before bone augmentation vs Plastic curettes plus saline solution before bone augmentation

Change in soft tissue recession (REC) · People with at least one dental implant affected by perimplantitis

Er:YAG laser surface debridement before bone augmentation showed no clear difference in change in soft tissue recession (REC) compared with plastic curettes plus saline solution before bone augmentation; GRADE not reported.

1 finding from 1 review

1-stage (non-submerged) implant placement vs 2-stage (submerged) implant placement

Aesthetics evaluated by dentists (soft tissue recession) · People with dental implants

1-stage (non-submerged) implant placement showed no clear difference in aesthetics evaluated by dentists (soft tissue recession) compared with 2-stage (submerged) implant placement; GRADE not reported.

1 finding from 1 review

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Adverse effects (tooth staining/discoloration, oral soft-tissue signs, adverse symptoms such as nausea/vomiting, enamel etching) · Children and adolescents aged 16 years or less
1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Comfort · Adults with refractive errors

The review found no eligible studies for this question.

3 findings from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Proportion of participants who discontinued contact lens wear, at 1 week (RR < 1 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes proportion of participants who discontinued contact lens wear, at 1… compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Corneal staining scores, at 1 week (MD < 0 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes corneal staining scores, at 1 week (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review

Silicone hydrogel vs hydrogel soft contact lenses

Conjunctival staining scores, at 1 month (MD < 0 favored) · Adults with refractive errors

It is very uncertain whether silicone hydrogel changes conjunctival staining scores, at 1 month (MD < 0 favored) compared with hydrogel soft contact lenses (very low certainty).

1 finding from 1 review