Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

211 questions · 253 findings · 24 reviews · Oral and maxillofacial surgery

No studies found 32 · 12.6%GRADE not reported 183 · 72.3%Very low 25 · 9.9%Low 7 · 2.8%Moderate 6 · 2.4%High 0 · 0%

Autologous platelet‐rich plasma vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

It is very uncertain whether platelet rich plasma changes presence of dry socket compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Chlorhexidine 0.2% socket irrigation (monoject syringe) vs Chlorhexidine 0.2% mouthrinse

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine 0.2% socket irrigation (monoject syringe) led to lower presence of dry socket compared with chlorhexidine 0.2% mouthrinse; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel (0.2%, intrasocket) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.12%) (low certainty).

1 finding from 1 review

Tap water irrigation (monoject syringe) vs No rinsing

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Tap water irrigation (monoject syringe) led to lower presence of dry socket compared with no rinsing; GRADE not reported.

1 finding from 1 review

Chlorhexidine gel vs Chlorhexidine, 0.2% to 2% (solution or gel)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel 1% showed no clear difference in presence of dry socket compared with chlorhexidine gel 0.2%; GRADE not reported.

1 finding from 1 review

Honey (Manuka, topical) vs Chlorhexidine rinse (0.2%)

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Honey (Manuka, topical) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%); GRADE not reported.

1 finding from 1 review

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Presence of dry socket · Adults (>18 years) having permanent tooth extraction (predominantly mandibular third molars)

Chlorhexidine gel (0.2%, intrasocket) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Pain (dichotomous, present/absent on 6th-7th day) · People undergoing tooth extraction (21 of 23 trials: healthy patients undergoing impacted third molar extraction; 1 routine intra-alveolar…

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes presence of pain (dichotomous, yes/no on 6th-7th day) compared with placebo (very low certainty).

1 finding from 1 review

Mandibular third molar present vs Mandibular third molar absent

Spontaneous space closure · Children and adolescents after extraction of a mandibular permanent first molar (before eruption of the second molar)

In the mandible, presence of the third molar increases odds of spontaneous space closure (OR 2.28; low certainty).

1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence proportion) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence proportion) compared with standard care (very low certainty).

1 finding from 1 review

Dental examinations at three-month intervals and preventive treatments vs usual care

MRONJ (incidence rate: cases per patient-year) · Men with metastatic prostate cancer receiving intravenous zoledronic acid (at risk of MRONJ)

It is very uncertain whether dental examinations at three-month intervals and preventive treatments changes MRONJ (incidence rate: cases per patient-year) compared with standard care (very low certainty).

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Clinical assessment: alveolar ridge healing (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher clinical assessment: alveolar ridge healing (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: periapical film (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: periapical film (0 to 3 grading scale) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Length of hospital stay · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to lower length of hospital stay (days) compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Postoperative complication: persistent oronasal fistula · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… showed no clear difference in postoperative complication: persistent oronasal fistula compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review

Artificial bone graft: InFuse (collagen matrix) impregnated with rhBMP-2 vs Traditional iliac crest cancellous bone graft

Radiographic assessment: three-dimensional CT scan (0 to 3 grading scale) · Skeletally mature patients with unilateral cleft lip and palate and an alveolar cleft defect (>5 years; mean age 16.1 years)

Artificial bone graft: InFuse (collagen matrix) impregnated with… led to higher radiographic assessment: three-dimensional CT scan (0 to 3 grading… compared with traditional iliac crest cancellous bone graft; GRADE not reported.

1 finding from 1 review