Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

668 questions · 685 findings · 68 reviews · Headline outcomes only

No studies found 181 · 26.4%GRADE not reported 16 · 2.3%Very low 151 · 22%Low 211 · 30.8%Moderate 98 · 14.3%High 28 · 4.1%

Intervention not reported

Aldosterone antagonists plus paracentesis plus fluid replacement (1 RCT; 36 participants) · people with liver cirrhosis and ascites

The intervention may leads to higher aldosterone antagonists plus paracentesis plus fluid replacement (1… (low certainty).

1 finding from 1 review

Intervention not reported

Aldosterone antagonists plus loop diuretics plus paracentesis plus fluid replacement (No direct RCT) · people with liver cirrhosis and ascites

It is very uncertain whether the intervention changes aldosterone antagonists plus loop diuretics plus paracentesis plus… (very low certainty).

1 finding from 1 review

Intervention not reported

Requirement for renal replacement therapy ( · adult (≥ 18 years of age) patients receiving mechanical ventilation (via either an endotracheal tube or a tracheostomy) for acute…

It is very uncertain whether the intervention changes requirement for renal replacement therapy ( (very low certainty).

1 finding from 1 review

Tenckhoff catheter with artificial curve at tunnel tract vs swan‐neck

Catheter removal or replacement · preventing catheter‐related infections in chronic peritoneal dialysis patients

Tenckhoff catheter with artificial curve at tunnel tract showed no clear difference in catheter removal or replacement compared with swan‐neck (moderate certainty).

1 finding from 1 review

Self‐locating vs straight Tenckhoff catheter

Catheter removal or replacement · chronic peritoneal dialysis patients

It is very uncertain whether self‐locating changes catheter removal or replacement compared with straight Tenckhoff catheter (very low certainty).

1 finding from 1 review

Any washout vs no washout

Number of catheters used (Number of participants needing catheter replacement, saline washout versus no washout) · Long‐term indwelling urinary catheterisation in adults

It is very uncertain whether any washout changes number of catheters used (Number of participants needing catheter… compared with no washout (very low certainty).

1 finding from 1 review

Oral or topical or intraperitoneal antibiotics vs placebo/no treatment

Catheter removal or replacement · chronic peritoneal dialysis patients

Oral or topical or intraperitoneal antibiotics showed no clear difference in catheter removal or replacement (number of patients) compared with placebo/no treatment (low certainty).

1 finding from 1 review

Topical disinfectants vs standard care or other active treatment (antibiotic or other disinfectant)

Catheter removal or replacement · chronic peritoneal dialysis patients

Topical disinfectants showed no clear difference in catheter removal or replacement (number of patients) compared with standard care or other active treatment (antibiotic or other… (low certainty).

1 finding from 1 review