Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 205 findings · 42 reviews

No studies found 23 · 11.2%GRADE not reported 64 · 31.2%Very low 31 · 15.1%Low 51 · 24.9%Moderate 33 · 16.1%High 3 · 1.5%

Intermediate restorative material (IRM) root-end filling vs SuperEBA

Healing - 1 year or longer · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether intermediate restorative material (IRM) root-end filling changes healing - 1 year or longer compared with superEBA (very low certainty).

1 finding from 1 review

Intermediate restorative material (IRM) root-end filling vs Gutta-percha

Healing - 1 year or longer · People requiring retreatment of periapical lesions (failed root canal therapy)

It is very uncertain whether intermediate restorative material (IRM) root-end filling changes healing - 1 year or longer compared with gutta-percha (very low certainty).

1 finding from 1 review

Intervention not reported

Behavioural outcome: colorectal cancer screening IVR, unidirectional ATCS versus usual care or letter at longer (9‐12 months) · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The intervention showed no clear difference in behavioural outcome: colorectal cancer screening IVR, unidirectional… (moderate certainty).

1 finding from 1 review

CBT vs WAIT LIST

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT probably leads to higher remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting… compared with wait‐list (moderate certainty).

1 finding from 1 review

CBT vs active control

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT) analysis i.e. no longer meeting… compared with active controls (moderate certainty).

1 finding from 1 review

CBT vs treatment

Remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting criteria for DSM or ICD anxiety diagnosis at the end of the trial. · children and adolescents with anxiety disorders

CBT showed no clear difference in remission of anxiety diagnoses (ITT analysis) i.e. no longer meeting… compared with treatment (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: severe hypoxaemiaAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: severe hypoxaemiaAlive… compared with supine (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: lower tidal volume ventilationAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: lower tidal volume… compared with supine (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: ARDS onlyAlive or dead · adults with acute respiratory failure

Mortality: prone position showed no clear difference in subgroup analysis of longer‐term mortality: ARDS onlyAlive or dead compared with supine (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: ≥ 16 hours/d proneAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: ≥ 16 hours/d proneAlive… compared with supine (moderate certainty).

1 finding from 1 review

Mortality: prone position vs supine

Subgroup analysis of longer‐term mortality: enrolment ≤ 48 hours after entry criteria/ventilationAlive or dead · adults with acute respiratory failure

Mortality: prone position probably leads to lower subgroup analysis of longer‐term mortality: enrolment ≤ 48 hours… compared with supine (moderate certainty).

1 finding from 1 review

Exercise therapy vs a control strategy (no treatment, placebo or waiting list controls)

Recovered · patients with patellofemoral pain syndrome (symptoms > 3 weeks (1 study); symptoms > 1 month (3 studies); symptoms > 2 months (2 studies);…

It is very uncertain whether exercise therapy changes recovery (long‐term) Number of patients who had recovered or number… compared with a control strategy (no treatment, placebo or waiting list controls) (very low certainty).

1 finding from 1 review