Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 156 findings · 14 reviews · Headline outcomes only

No studies found 45 · 28.8%GRADE not reported 3 · 1.9%Very low 53 · 34%Low 31 · 19.9%Moderate 16 · 10.3%High 8 · 5.1%

Risk of transient neurological symptoms with spinal lidocaine vs other local anaesthetic

Presence of any TNS – lidocaine vs ropivacaine · adults undergoing surgery

Risk of transient neurological symptoms with spinal lidocaine may leads to lower presence of any TNS – lidocaine vs ropivacaine compared with other local anaesthetic (low certainty).

1 finding from 1 review

Lidocaine IV vs placebo or no treatment

Nausea · adults undergoing surgery with general anaesthesia

It is very uncertain whether intravenous (IV) lidocaine changes postoperative nausea, 'overall' (0 to 24 h, to 48 h, to 72 h) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs lidocaine intraperitoneal instillation alone

Number of women requiring rescue medication · women undergoing PPTL under local anaesthesia

Combination of lidocaine intraperitoneal instillation plus… showed no clear difference in number of women requiring rescue medication compared with lidocaine intraperitoneal instillation alone (low certainty).

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Intraoperative pain or discomfort (dichotomous data) · adults undergoing phacoemulsification cataract surgery

Topical anaesthesia plus intracameral lidocaine probably leads to lower intraoperative pain or discomfort (dichotomous data) compared with topical anaesthesia alone (moderate certainty).

1 finding from 1 review