Cochrane · systematic review · CD009642
Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery in adults
Weibel, S, Jelting, Y, Pace, NL, et al. · Cochrane Database of Systematic Reviews · 2018 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
8
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 2 · 20%Very low 8 · 80%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 2 versionsIntravenous (IV) lidocaine compared to placebo or no treatment in patients undergoing any elective or urgent surgical procedure under general anaesthesia
Population: adult patients undergoing any elective or urgent surgical procedure under general anaesthesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain (VAS 0 to 10 cm, 0 to 100 mm, NRS 0 to 10) Intravenous (IV) lidocaine vs placebo or no treatment | no estimate extracted | 29 studies · 1656 participants | Very low Downgraded: risk of bias |
Gastrointestinal recovery Intravenous (IV) lidocaine vs placebo or no treatment | RR 0.37 [0.15, 0.87] | 4 studies · 273 participants | Very low Downgraded: risk of bias |
Adverse events (e.g. the number of participants that died, or had arrhythmias, other heart rate disorders, or showed any signs of lidocaine toxicity) Intravenous (IV) lidocaine vs placebo or no treatment | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency, publication bias |
Postoperative nausea, 'overall' (0 to 24 h, to 48 h, to 72 h) Intravenous (IV) lidocaine vs placebo or no treatment | RR 0.78 [0.67, 0.91] | 35 studies · 1903 participants | Very low Downgraded: risk of bias |
Postoperative opioid consumption, 'overall' (MEQ, mg) Intravenous (IV) lidocaine vs placebo or no treatment | no estimate extracted | 40 studies · 2201 participants | Very low Downgraded: risk of bias |
Intravenous (IV) lidocaine compared to thoracic epidural analgesia (TEA) in patients undergoing any elective or urgent surgical procedure under general anaesthesia
Population: adult patients undergoing any elective or urgent surgical procedure under general anaesthesia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Pain (VAS 0 to 10 cm, 0 to 100 mm, NRS 0 to 10 Intravenous (IV) lidocaine vs thoracic epidural analgesia (TEA) | no estimate extracted | 0 studies · 0 participants | Ungraded |
Gastrointestinal recovery Intravenous (IV) lidocaine vs thoracic epidural analgesia (TEA) | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Adverse events (e.g. the number of participants that died, or had arrhythmias, other heart rate disorders, or showed any signs of lidocaine toxicity) Intravenous (IV) lidocaine vs thoracic epidural analgesia (TEA) | no estimate extracted | NR | Very low Downgraded: risk of bias, imprecision, inconsistency |
Postoperative nausea, 'overall' (0 to 24 h, to 48 h, to 72 h) Intravenous (IV) lidocaine vs thoracic epidural analgesia (TEA) | no estimate extracted | 1 study · 60 participants | Very low Downgraded: risk of bias, imprecision, inconsistency |
Postoperative opioid consumption, 'overall' (MEQ, mg) Intravenous (IV) lidocaine vs thoracic epidural analgesia (TEA) | no estimate extracted | 0 studies · 0 participants | Ungraded |