New white spot lesion incidence (and first-time bracket bond failure) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single multicenter RCT found resin-modified glass-ionomer cement did not reduce new white spot lesions or bond failures versus conventional composite (ungraded).
1 finding from 1 review
Enamel demineralization / white spot lesion prevention (DIAGNOdent, enamel mineral content) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
Two small RCTs gave inconsistent results for TiO2-modified adhesives/composites on enamel demineralization (one favorable on DIAGNOdent, one no difference in mineral content); ungraded.
1 finding from 1 review
White spot lesion rate and volume · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Clearfil Protect Bond showed no WSL-rate difference versus conventional adhesive, with certainty not graded.
1 finding from 1 review
There was no significant difference among the WSL rates of the Clearfil, Opal Seal, and Transbond XT adhesives (p > 0.05).
1 study · 15 participants
GRADE not reported
Enamel mineral content · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Chitosan and TiO2 adhesive showed no enamel mineral-content difference, with certainty not graded.
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)
Prior SDF without a rinsing step significantly reduces adhesive bond strength to sound dentin (MD 17.52 MPa favoring untreated dentin, 95% CI 5.81 to 29.22; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives/resin composite bonded to dentin (in vitro), sound or caries-affected
Prior SDF application significantly reduces the immediate bond strength of adhesives to dentin overall (MD 7.12 MPa favoring untreated dentin, 95% CI 1.38 to 12.85; ungraded), with very high heterogeneity (I2=98%).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to sound dentin (in vitro)
A rinsing step after SDF eliminates the negative effect on adhesive bond strength to sound dentin (MD 7.11 MPa, 95% CI -0.57 to 14.79, non-significant; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)
Prior SDF followed by a rinsing step significantly increases adhesive bond strength to caries-affected dentin (MD -4.79 MPa favoring SDF, 95% CI -9.19 to -0.40; ungraded).
1 finding from 1 review
Immediate bond strength (MPa) · Dental adhesives bonded to caries-affected dentin (in vitro)
Only one study assessed SDF without a rinsing step on adhesive bonding to caries-affected dentin (Kucukyilmaz 2016, which reported impaired bond strength); no meta-analysis was possible, so no pooled estimate is available.
1 finding from 1 review
Peri-implant clinical and radiographic parameters (plaque index, probing depth, bone loss, pro-inflammatory profile) · Adult e-cigarette (ENDS) users with dental implants (incl. male implant-supported prosthesis patients)
Among dental implant patients, e-cigarette users show worse peri-implant parameters (more plaque, worse clinical and radiographic outcomes) than non-smokers (narrative synthesis; ungraded).
1 finding from 1 review
Clinical effectiveness · Children with carious primary teeth
No eligible randomized clinical trials of bio-active restorative materials were found.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Discomfort associated with the procedure · People with dental caries in primary teeth (mainly children)
The reported estimate for discomfort with ART versus conventional treatment was inconclusive (ungraded).
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)
Glass ionomer cement did not show a statistically significant difference in new white spot lesions versus resin adhesive (very low certainty).
1 finding from 1 review
Initiation of white spot lesions (WSL), visual-tactile assessment · Patients of any age (11-40 years) receiving comprehensive/fixed orthodontic treatment with fixed appliances
There is no clear difference in WSL initiation between glass ionomer cement and resin adhesive for bracket bonding (RR 0.72, not significant); certainty of evidence is very low.
1 finding from 1 review
Periodontal/peri-implant status (secondary outcomes) · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region
The review found no eligible studies for this question.
1 finding from 1 review
Aesthetics · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
The review found no eligible studies for this question.
1 finding from 1 review
Bridge failure · Adults (18 years or older) needing a three-unit fixed dental prosthesis (FDP)
1 finding from 1 review
Bridge complications · Adults (18 years or older) needing an implant-supported fixed dental prosthesis in the posterior region
It is very uncertain whether metal-free implant-supported FDPs (zirconia-toughened alumina;… changes bridge complications compared with metal-free implant-supported FDPs (yttria-stabilized tetragonal… (very low certainty).
4 findings from 1 review
OR 0.02 [0.00, 0.42]
1 study · 18 participants
Very low
OR 0.02 [0.00, 0.30]
1 study · 18 participants
Very low
OR 0.04 [0.00, 0.48]
1 study · 18 participants
Very low
Show 1 more finding
Plaque · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
Metal-free cantilevered FDPs (feldspathic-veneered zirconia) showed no clear difference in plaque index (PI) compared with metal-ceramic cantilevered FDPs; GRADE not reported.
1 finding from 1 review
Cantilevered bridge failure · Adults (18 years or older) needing replacement of one premolar or incisor with a cantilevered fixed dental prosthesis
1 finding from 1 review