Findings

What do systematic reviews say?

1,773 questions · 1,817 findings · 212 reviews · Headline outcomes only

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No studies found 383 · 21.1%GRADE not reported 192 · 10.6%Very low 472 · 26%Low 444 · 24.4%Moderate 228 · 12.5%High 98 · 5.4%

Continuous chest compression plus ventilation vs interrupted chest compression plus artificial ventilation

Adverse effects Defined as any adverse event occurring post‐admission · Patients with non‐trauma related out‐of‐hospital cardiac arrest

1 finding from 1 review

Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23711 participants
Moderate

Continuous chest compression plus ventilation vs interrupted chest compression plus artificial ventilation

Quality of life · Patients with non‐trauma related out‐of‐hospital cardiac arrest

1 finding from 1 review

Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Continuous chest compression plus ventilation vs interrupted chest compression plus artificial ventilation

Survival to hospital discharge · Patients with non‐trauma related out‐of‐hospital cardiac arrest

1 finding from 1 review

Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23648 participants
Moderate

Continuous chest compression plus ventilation vs interrupted chest compression plus artificial ventilation

Survival to hospital admission · Patients with non‐trauma related out‐of‐hospital cardiac arrest

1 finding from 1 review

Continuous chest compression versus interrupted chest compression for cardiopulmonary resuscitation of non‐asphyxial… 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 23711 participants
High

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Intraoperative pain or discomfort (continuous data) · adults undergoing phacoemulsification cataract surgery

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine versus topical anaesthesia alone for phacoemulsification cataract… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Intraoperative pain or discomfort (dichotomous data) · adults undergoing phacoemulsification cataract surgery

Topical anaesthesia plus intracameral lidocaine probably leads to lower intraoperative pain or discomfort (dichotomous data) compared with topical anaesthesia alone (moderate certainty).

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine versus topical anaesthesia alone for phacoemulsification cataract… 2020 · Cochrane Headline outcomes only
OR 0.4 [0.29, 0.57]
Studies not reported
Moderate

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Discomfort/pain · adults undergoing phacoemulsification cataract surgery

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine versus topical anaesthesia alone for phacoemulsification cataract… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Participant satisfaction · adults undergoing phacoemulsification cataract surgery

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine versus topical anaesthesia alone for phacoemulsification cataract… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Mean change of endothelial cell loss · adults undergoing phacoemulsification cataract surgery

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine versus topical anaesthesia alone for phacoemulsification cataract… 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Moderate

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Need for analgesic prescription for pain (supplemental analgesic requirements) · breast cancer surgery

Paravertebral anaesthesia with or without sedation may leads to lower postoperative analgesic requirement compared with general anaesthesia (low certainty).

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
OR 0.07 [0.01, 0.34]
5 studies · 305 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Number of patients with postoperative nausea and vomiting (postoperative care unit) · breast cancer surgery

Paravertebral anaesthesia with or without sedation probably leads to lower postoperative nausea and vomiting (PONV) compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
OR 0.16 [0.08, 0.3]
6 studies · 323 participants
Moderate

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Postoperative pain at 2 hours · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 224 participants
Moderate

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Postoperative pain at 24 hours on rest · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 169 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Postoperative pain at 6 hours on movement · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 130 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Pain (VAS scores) on movement at postoperative day 1 Scale from: 0 to 10. · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 130 participants
Low

Paravertebral anaesthesia with or without sedation vs general anaesthesia

All‐cause mortality · breast cancer surgery

1 finding from 1 review

Paravertebral anaesthesia with or without sedation versus general anaesthesia for women undergoing breast cancer surgery 2021 · Cochrane Headline outcomes only
no estimate extracted
9 studies · 9 participants
GRADE not reported

What is the effect of general anaesthesia including nitrous oxide vs without nitrous oxide on the risk of accidental awareness during general anaesthesia

Accidental awareness ‐ Overall (AAGA) · surgical patients

1 finding from 1 review

Nitrous oxide‐based versus nitrous oxide‐free general anaesthesia and accidental awareness during general anaesthesia… 2016 · Cochrane Headline outcomes only
no estimate extracted
14 studies · 3439 participants
Very low

What is the effect of general anaesthesia including nitrous oxide vs without nitrous oxide on the risk of accidental awareness during general anaesthesia

Accidental awareness ‐ In recovery (AAGA) · surgical patients

1 finding from 1 review

Nitrous oxide‐based versus nitrous oxide‐free general anaesthesia and accidental awareness during general anaesthesia… 2016 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 263 participants
Very low

What is the effect of general anaesthesia including nitrous oxide vs without nitrous oxide on the risk of accidental awareness during general anaesthesia

Accidental awareness ‐ 24 hours (AAGA) · surgical patients

1 finding from 1 review

Nitrous oxide‐based versus nitrous oxide‐free general anaesthesia and accidental awareness during general anaesthesia… 2016 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 556 participants
Very low

Analysis 7 ‐ Collagen membrane with polyethylene glycol and glycerol vs Ringer's lactate

Adhesion score · patients with adhesion prevention after gynaecological surgery

1 finding from 1 review

Barrier agents for adhesion prevention after gynaecological surgery 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 47 participants
Very low