evidencegaps
Cochrane · systematic review · CD011052

Nitrous oxide‐based versus nitrous oxide‐free general anaesthesia and accidental awareness during general anaesthesia in surgical patients

Hounsome, J, Nicholson, A, Greenhalgh, J, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library

AnaesthesiaAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
3
current version
GRADE rated
3
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 3 · 100%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Questions and results

What is the effect of general anaesthesia including nitrous oxide compared to without nitrous oxide on the risk of accidental awareness during general anaesthesia in patients aged five years and over?

Population: surgical patients
3 questions
OutcomeEffectEvidenceStatus / GRADE
Accidental awareness ‐ Overall (AAGA)
What is the effect of general anaesthesia including nitrous oxide vs without nitrous oxide on the risk of accidental awareness during general anaesthesia
no estimate extracted14 studies · 3439 participantsVery low
Downgraded: risk of bias
Accidental awareness ‐ In recovery (AAGA)
What is the effect of general anaesthesia including nitrous oxide vs without nitrous oxide on the risk of accidental awareness during general anaesthesia
no estimate extracted5 studies · 263 participantsVery low
Downgraded: risk of bias
Accidental awareness ‐ 24 hours (AAGA)
What is the effect of general anaesthesia including nitrous oxide vs without nitrous oxide on the risk of accidental awareness during general anaesthesia
no estimate extracted7 studies · 556 participantsVery low
Downgraded: risk of bias