Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,355 questions · 2,459 findings · 279 reviews

No studies found 556 · 22.6%GRADE not reported 490 · 19.9%Very low 593 · 24.1%Low 479 · 19.5%Moderate 243 · 9.9%High 98 · 4%

Remineralizing orthodontic adhesives vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Enamel remineralization / anti-demineralization extent · Human teeth with early enamel lesions surrounding orthodontic brackets

No meta-analysis was conducted; most included in vitro studies reported significant remineralization with remineralizing orthodontic adhesives versus controls.

1 finding from 1 review

Remineralizing orthodontic adhesives vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

Ion release · Human teeth with early enamel lesions surrounding orthodontic brackets

No meta-analysis was conducted; most studies reported increased ion release over time, but few reported peak values.

1 finding from 1 review

Adhesive flash-free ceramic brackets vs Adhesive precoated ceramic brackets

Enamel demineralization (QLF ΔF) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Flash-free brackets showed no clinical WSL reduction, with certainty not graded.

1 finding from 1 review

Opal Seal fluoride-releasing adhesive vs Conventional/control orthodontic adhesive (e.g., Transbond XT) or negative control

White spot lesion rate and volume · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Opal Seal showed no significant difference in WSL rate or volume, with certainty not graded.

1 finding from 1 review

Topical anaesthesia plus intracameral lidocaine vs topical anaesthesia alone

Intraoperative pain or discomfort (dichotomous data) · adults undergoing phacoemulsification cataract surgery

Topical anaesthesia plus intracameral lidocaine probably leads to lower intraoperative pain or discomfort (dichotomous data) compared with topical anaesthesia alone (moderate certainty).

1 finding from 1 review

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Need for analgesic prescription for pain (supplemental analgesic requirements) · breast cancer surgery

Paravertebral anaesthesia with or without sedation may leads to lower postoperative analgesic requirement compared with general anaesthesia (low certainty).

1 finding from 1 review

Paravertebral anaesthesia with or without sedation vs general anaesthesia

Number of patients with postoperative nausea and vomiting (postoperative care unit) · breast cancer surgery

Paravertebral anaesthesia with or without sedation probably leads to lower postoperative nausea and vomiting (PONV) compared with general anaesthesia (moderate certainty).

1 finding from 1 review