Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

535 questions · 545 findings · 129 reviews · Headline outcomes only

No studies found 131 · 24%GRADE not reported 30 · 5.5%Very low 123 · 22.6%Low 136 · 25%Moderate 98 · 18%High 27 · 5%

Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone

Procedure‐related adverse events within 3 months · people with acute ischemic stroke

Thrombo‐aspiration alone showed no clear difference in procedure‐related adverse events within 3 months compared with stent‐retrieval thrombectomy alone (high certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Iron deficiency anaemia · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in iron deficiency anaemia (as defined by the presence of anaemia plus… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Side effects or other adverse events · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in any adverse side effects compared with no supplementation or placebo (moderate certainty).

1 finding from 1 review

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Any adverse effects (hookworm infection risk) · general population of all age groups (including pregnant women) from any country, over two years of age

Rice fortified with iron alone or in combination with other… may leads to higher any adverse effects (hookworm infection risk) compared with unfortified rice (no micronutrients added) (low certainty).

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

5c. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram as an adjunct to methylxanthine compared to methylxanthine alone for the treatment of apnea · treatment of apnea

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

5c. Moderate‐to‐severe neurodevelopmental disability or intellectual impairment after 2 years of age – doxapram as an adjunct to methylxanthine compared to methylxanthine alone for the prevention of reintubation · prevention of reintubation

The review found no eligible studies for this question.

1 finding from 1 review

Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or

side‐effects ‐ side‐effects causing abandon · prevention of reintubation

It is very uncertain whether doxapram changes 6c. Side effects causing cessation of therapy – doxapram as an… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty).

1 finding from 1 review

Intervention not reported

Number of patients with arrhythmia: Garlicin injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

It is very uncertain whether the intervention changes number of patients with arrhythmia: Garlicin injection plus… (very low certainty).

1 finding from 1 review

Intervention not reported

Number of patients with arrhythmia: Danhong injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

The intervention showed no clear difference in number of patients with arrhythmia: Danhong injection plus… (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of patients with premature beat: Shortscape Fleabane injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

The intervention showed no clear difference in number of patients with premature beat: Shortscape Fleabane… (low certainty).

1 finding from 1 review

Intervention not reported

Number of patients with premature beat: Astragaloside injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

The intervention showed no clear difference in number of patients with premature beat: Astragaloside injection plus… (low certainty).

1 finding from 1 review

Intervention not reported

Number of patients with premature beat: Danhong injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

The intervention probably leads to lower number of patients with premature beat: Danhong injection plus… (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of patients with arrhythmia: Astragaloside injection plus supportive therapy versus supportive therapy alone · patients with viral myocarditis

It is very uncertain whether the intervention changes number of patients with arrhythmia: Astragaloside injection plus… (very low certainty).

1 finding from 1 review