Dental caries · Children (<18 years) with vs without dental caries
FokI(rs2228570) over-dominant model: AA+GG vs AG was not significantly associated with dental caries (OR 1.04); ungraded.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
ApaI(rs7975232) allelic model: C vs A was not significantly associated with dental caries (OR 0.89); ungraded.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
Over-dominant model (CC+TT vs CT) at FokI(rs10735810) showed no significant association with caries (OR 0.83); ungraded.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
FokI(rs2228570) allelic model: A vs G was not significantly associated with dental caries (OR 1.07); ungraded.
1 finding from 1 review
Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy
For prenatal vitamin D measured across gestational weeks 6-38, the OR of dental caries was 1.32 (no CI reported); ungraded.
3 findings from 1 review
Dental caries in children · Children aged 6 to 8 years whose mothers' prenatal vitamin D status was assessed
In the single study of children aged 6-8 years, the association was not statistically significant (OR 1.07, 95% CI 0.84-1.30); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesPrenatal exposure; dental caries at 6 to 8 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 6 to 8 years
OR 1.07 [0.84, 1.30]
1 study
GRADE not reported
Dental caries in children · Infants and children (aged about 2 to 8 years) whose mothers' vitamin D status was assessed during pregnancy
For prenatal vitamin D measured across gestational weeks 24-38, the OR of dental caries was 1.30 (no CI reported); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesMaternal 25(OH)D measured at gestational weeks 24 to 38 · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Gestational-age subgroup: weeks 24 to 38
OR 1.30 [1.15, 1.45]
4 studies
GRADE not reported
Dental caries in children · Children aged 4 to 6 years whose mothers' prenatal vitamin D status was assessed
Among children aged 4-6 years, prenatal vitamin D deficiency is associated with significantly higher odds of dental caries (OR 1.44, 95% CI 1.32-1.56); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesPrenatal exposure; dental caries at 4 to 6 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 4 to 6 years
OR 1.44 [1.32, 1.56]
8 studies
GRADE not reported
Proportion of children with treated/untreated caries (receipt of dental care) · School children, primary schools in the USA
It is very uncertain whether referral letter based on the common-sense model (CSM) of… changes proportion of children with treated/untreated caries (receipt of… compared with standard referral letter (very low certainty).
1 finding from 1 review
Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Fluorescence devices for the detection of dental caries 2020 · Cochrane All outcomesUp to 3 months between index test and reference standard (in vivo studies)
Analysed as a separate index test (coupled forest plot and SROC plot, Figure 24 / Figure 25; Appendix 5); no summary DOR or sensitivity/specificity point reported numerically in the text. 18 datasets, 2402 tooth sites.
17 studies
GRADE not reported
Diagnostic accuracy (sensitivity and specificity) for detection of early enamel caries (D1 threshold) · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…
1 finding from 1 review
Poor oral health-related quality of life (OHRQoL) · Children aged 3-12 years
Higher dental caries experience was associated with substantially higher odds of poor OHRQoL (OR 1.66, 95% CI 1.43-1.88; 6 studies; high heterogeneity I2=83.5%; ungraded).
1 finding from 1 review
OR 1.66 [1.43, 1.88]
6 studies
GRADE not reported
Caries in primary teeth: dmft (3 years) · Children and adolescents with juvenile idiopathic arthritis (JIA)
There was no significant difference in dental caries of the primary teeth (dmft) between children with JIA and healthy peers (pooled MD -1.16, 95% CI -3.02 to 0.71; 3 cross-sectional studies; very high heterogeneity I2=87.9%; ungraded).
1 finding from 1 review
Dental caries in permanent teeth · Children and adolescents with juvenile idiopathic arthritis (JIA)
There was no significant difference in dental caries of the permanent teeth (DMFT) between children/adolescents with JIA and healthy peers (pooled MD -0.08, 95% CI -0.42 to 0.26; 6 cross-sectional studies; no heterogeneity I2=0%; ungraded).
1 finding from 1 review
Development of >=1 new carious lesion (caries incidence) · Children (high caries risk) with permanent molars requiring pit-and-fissure sealants
Caries incidence was 10% with laser-plus-acid versus 22% with acid-etching at 18 months, a non-significant difference (ungraded, single study).
1 finding from 1 review
Durmus 2017 (Er:YAG laser+acid vs acid-etching): caries incidence 10% (n=8) in the laser-plus-acid group vs 22% (n=18) in the acid-etching group at 18 months; difference not statistically significant (P > 0.05).
1 study · 51 participants
GRADE not reported
Incremental cost‐effectiveness · Children younger than 6 years (healthy except for dental caries)
In children younger than 6 years, OHPPs were associated with lower cost per DMFT/S (OR 0.07, 95% CI 0.02 to 0.32; ungraded).
1 finding from 1 review
Cost‐effectiveness · Children aged 6 years and older (healthy except for dental caries)
In children aged 6 years and older, the cost-effectiveness estimate was extremely imprecise and not significant (OR 0.00, 95% CI 0.00 to 48704.6; ungraded).
1 finding from 1 review
Incremental cost‐effectiveness · Children with dental caries
OHPPs were associated with a lower program cost per DMFT/S in about 97 of 100 programs (OR 0.03, 95% CI 0.01 to 0.11; ungraded, very high heterogeneity I2=99%).
1 finding from 1 review
OR 0.03 [0.01, 0.11]
8 studies
GRADE not reported
Dental caries · Children or adolescents
Children with iron deficiency anemia are over three times more likely to have dental caries than non-anemic children (OR 3.64, 95% CI 2.45 to 5.40; moderate certainty).
1 finding from 1 review
Dental caries susceptibility · Age group: Children (n=4) individuals with caries/high caries and controls
The pooled odds ratio was 0.98 (95% CI 0.87 to 1.10).
1 finding from 1 review
OR 0.98 [0.87, 1.10]
4 studies
GRADE not reported