Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

518 questions · 558 findings · 63 reviews

No studies found 77 · 13.8%GRADE not reported 143 · 25.6%Very low 89 · 15.9%Low 137 · 24.6%Moderate 95 · 17%High 17 · 3%

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pre‐eclampsia, or pregnancy loss, or stillbirth (or combination) at… compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Severe maternal morbidity and mortality index · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in severe maternal morbidity and mortality index compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Pregnancy loss or stillbirth at any gestational age · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in pregnancy loss or stillbirth at any gestational age compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Calcium supplementation/fortification vs placebo (outcomes

Caesarean section · women who are not yet pregnant and women in the early stages of pregnancy

Calcium supplementation showed no clear difference in caesarean section compared with placebo (maternal outcomes) commencing before or early (low certainty).

1 finding from 1 review

Partial pulpotomy (PP) with calcium hydroxide vs Direct pulp capping (DPC) with calcium hydroxide

Overall success (composite of clinical and radiographic success) · Adults (>=18 y) with mature permanent teeth, carious exposure and normal/reversibly inflamed pulp

At 1 year, partial pulpotomy and direct pulp capping (both calcium hydroxide) gave similarly low success in reversibly inflamed pulps (34.5% vs 31.8%; ungraded, single trial).

2 findings from 1 review

Pulpotomy with Calcium Enriched Mixture (CEM) vs Pulpotomy with calcium hydroxide (Ca(OH)2)

Overall success (composite of clinical and radiographic success) · Human permanent teeth with irreversible pulpitis due to carious pulp exposure

CEM and calcium hydroxide did not differ significantly in pulpotomy success (indirect comparison); ungraded.

1 finding from 1 review