Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

859 questions · 901 findings · 80 reviews

No studies found 247 · 27.4%GRADE not reported 170 · 18.9%Very low 224 · 24.9%Low 136 · 15.1%Moderate 90 · 10%High 34 · 3.8%

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Acute necrotising ulcerative gingivitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Acute necrotising ulcerative gingivitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Recurrent oral ulcerations (WHO clinical stage 2) · Children or adolescents

CLWH on ART had significantly higher prevalence of recurrent oral ulcerations than healthy controls (pooled OR 6.83, 95% CI 1.18 to 39.53).

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in recurrent oral ulceration between ART regimens (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

Ulcerative stomatitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).

1 finding from 1 review

Living with HIV and undergoing antiretroviral therapy (ART/HAART) vs Healthy HIV-negative controls

Acute necrotizing ulcerative gingivitis/periodontitis (WHO clinical stage 3) · Children or adolescents

No eligible studies reported acute necrotizing ulcerative gingivitis/periodontitis.

1 finding from 1 review

Combined antiretroviral therapy (cART) vs Monotherapy or dual antiretroviral therapy

Acute necrotising ulcerative periodontitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in acute necrotising ulcerative periodontitis between ART regimens (very low certainty).

1 finding from 1 review

Antiretroviral therapy (any, including cART) vs No antiretroviral medication (treatment-naive)

Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)

No significant difference in recurrent oral ulceration between CLWH with and without ART (very low certainty).

1 finding from 1 review

Intervention not reported

Case control ‐ ulcerative colitis, MMR · children 9 months to 15 years old

The intervention showed no clear difference in case control ‐ ulcerative colitis, MMR (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Impulsive lifestyle counselling + treatment‐as‐usual vs usual care

Adverse events:incarceration Assessed by: incarceration between a 3‐ and 9‐month · adults with antisocial personality disorder

It is very uncertain whether impulsive lifestyle counselling + treatment‐as‐usual changes adverse events:incarceration Assessed by: incarceration between a 3‐… compared with treatment‐as‐usual alone (very low certainty).

1 finding from 1 review

Juvenile idiopathic arthritis (JIA) vs Children and adolescents without JIA (healthy peers)

Oral ulcerations · Children and adolescents with juvenile idiopathic arthritis (JIA)

A single study reported more oral ulcerations in children with JIA (5/41) than without JIA (1/41); evidence is limited to one study (ungraded).

1 finding from 1 review

Direct vision entry vs Veress needle entry

Visceral injury (bladder or bowel) · patients undergoing laparoscopy

It is very uncertain whether direct vision entry changes visceral injury (bladder or bowel) compared with veress needle entry (very low certainty).

1 finding from 1 review

Direct vision entry vs open‐entry technique

Visceral injury (bladder or bowel) · patients undergoing laparoscopy

It is very uncertain whether direct vision entry changes visceral injury (bladder or bowel) compared with open‐entry technique (very low certainty).

1 finding from 1 review

Radially expanding (STEP) trocars for primary port entry vs standard (non‐expanding) trocars

Visceral injury (bladder or bowel) · patients undergoing laparoscopy

It is very uncertain whether radially expanding (STEP) trocars for primary port entry changes visceral injury (bladder or bowel) compared with standard (non‐expanding) trocars (very low certainty).

1 finding from 1 review

Open‐entry vs closed entry technique

Visceral injury (bladder or bowel) · patients undergoing laparoscopy

It is very uncertain whether open‐entry changes visceral injury (bladder or bowel) compared with closed‐entry technique (very low certainty).

1 finding from 1 review

Direct trocar entry vs Veress needle entry

Visceral injury (bladder or bowel) · patients undergoing laparoscopic surgery

It is very uncertain whether direct trocar entry changes visceral injury (bladder or bowel) compared with veress needle entry (very low certainty).

1 finding from 1 review