Number of participants who experienced side effects related to use of bisphosphonates · Paget's disease of bone
Zoledronate showed no clear difference in number of participants who experienced side effects related to use… compared with pamidronate or risedronate (low certainty).
1 finding from 1 review
Complications and side effects · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
Complications and side effects · People treated with oral bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
MRONJ (incidence proportion) · People treated with oral bisphosphonates undergoing dental extractions (at risk of MRONJ)
1 finding from 1 review
In both study arms, no case of postoperative MRONJ was observed (700 participants; 1 RCT); effect not estimable.
1 study · 700 participants
GRADE not reported
MRONJ (incidence proportion) · People with cancer treated with intravenous bisphosphonates undergoing dental extractions (at risk of MRONJ)
It is very uncertain whether dental extraction protocol with plasma rich in growth factors (PRGF)… changes MRONJ (incidence proportion) compared with standard dental extraction protocol without PRGF (very low certainty).
1 finding from 1 review
Healing of osteonecrosis - improvement ('healed' or 'improved' vs 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - improvement ('healed' or 'improved' vs… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.
5 findings from 1 review
RR 1.75 [0.51, 5.98]
1 study · 18 participants
GRADE not reported
RR 1.78 [0.97, 3.28]
1 study · 46 participants
GRADE not reported
RR 1.94 [1.01, 3.74]
1 study · 45 participants
Very low
Show 2 more findings
Healing of osteonecrosis - healed ('healed' vs 'improved', 'unchanged' or 'worse') · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
Hyperbaric oxygen therapy plus standard care (surgery, antibiotics,… showed no clear difference in healing of osteonecrosis - healed ('healed' vs 'improved',… compared with standard care alone (surgery, antibiotics, oral rinse); GRADE not reported.
5 findings from 1 review
RR 1.56 [0.77, 3.18]
1 study · 46 participants
GRADE not reported
RR 1.00 [0.25, 4.00]
1 study · 18 participants
GRADE not reported
RR 0.95 [0.44, 2.04]
1 study · 40 participants
GRADE not reported
Show 2 more findings
Pain · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review
Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
0 studies
No studies found
Quality of life · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)
1 finding from 1 review
Intervention not reported
Overall survival## · patients with multiple myeloma
The intervention showed no clear difference in overall survival## (moderate certainty).
1 finding from 1 review
Intervention not reported
Progression‐free survival### · patients with multiple myeloma
The intervention showed no clear difference in progression‐free survival### (low certainty).
1 finding from 1 review
Intervention not reported
Vertebral fractures · patients with multiple myeloma
The intervention probably leads to lower vertebral fractures (moderate certainty).
1 finding from 1 review
Intervention not reported
Non‐vertebral fractures · patients with multiple myeloma
The intervention showed no clear difference in non‐vertebral fractures (moderate certainty).
1 finding from 1 review
Intervention not reported
Skeletal‐related events · patients with multiple myeloma
The intervention probably leads to lower skeletal‐related events (moderate certainty).
1 finding from 1 review
Intervention not reported
Pain · patients with multiple myeloma
It is very uncertain whether the intervention changes pain (very low certainty).
1 finding from 1 review
Intervention not reported
Osteonecrosis of jaw · patients with multiple myeloma
The intervention showed no clear difference in osteonecrosis of jaw (low certainty).
1 finding from 1 review
Number of participants who needed orthopaedic surgery (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in quality of life measures (not measured) · Paget's disease of bone
1 finding from 1 review
Number of participants with change in hearing thresholds (not measured) · Paget's disease of bone
1 finding from 1 review