Cochrane · systematic review · CD003188
Bisphosphonates in multiple myeloma: an updated network meta‐analysis
Mhaskar, R, Kumar, A, Miladinovic, B, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
7
current version
GRADE rated
7
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 14.3%Low 2 · 28.6%Moderate 4 · 57.1%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsSummary of findings (direct comparisons)
Population: patients with multiple myeloma
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Overall survival## | HR 0.9 [0.76, 1.07] | 14 studies · 2706 participants | Moderate Downgraded: risk of bias, inconsistency |
Progression‐free survival### | HR 0.75 [0.57, 1] | 7 studies · 908 participants | Low Downgraded: risk of bias, publication bias |
Vertebral fractures | RR 0.74 [0.62, 0.89] | 7 studies · 1116 participants | Moderate Downgraded: risk of bias, publication bias |
Non‐vertebral fractures | RR 1.03 [0.68, 1.56] | 6 studies · 1389 participants | Moderate Downgraded: risk of bias, publication bias |
Skeletal‐related events | RR 0.74 [0.63, 0.88] | 10 studies · 2141 participants | Moderate Downgraded: risk of bias, publication bias |
Pain | RR 0.75 [0.6, 0.95] | 8 studies · 1281 participants | Very low |
Osteonecrosis of jaw | RR 4.61 [0.99, 21.35] | 6 studies · 1284 participants | Low Downgraded: risk of bias, imprecision, inconsistency, publication bias |