Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

288 questions · 290 findings · 74 reviews · Headline outcomes only

No studies found 56 · 19.3%GRADE not reported 21 · 7.2%Very low 61 · 21%Low 62 · 21.4%Moderate 39 · 13.4%High 51 · 17.6%

Deferasirox vs placebo

AE: abnormal serum creatinine (post‐baseline) · people with non‐transfusion‐dependent thalassemia

It is very uncertain whether deferasirox changes AE: abnormal serum creatinine (post‐baseline) compared with placebo (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ZIPRASIDONE

Adverse effects: Specific ‐ clinically significant abnormal ECG during 72 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ clinically significant abnormal ECG… compared with OTHER ANTIPSYCHOTIC: j. ZIPRASIDONE (very low certainty).

1 finding from 1 review

Corticosteroids vs placebo

Congenital abnormalities · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes congenital abnormalities compared with placebo (very low certainty).

1 finding from 1 review

Routine/revealed vs selective/concealed ultrasound

Detection of fetal abnormality before 24 weeks' gestation · Fetal ultrasound assessment before 24 weeks' gestation

Routine/revealed probably leads to higher detection of fetal abnormality before 24 weeks' gestation compared with selective/concealed ultrasound (moderate certainty).

1 finding from 1 review

Bishop score vs transvaginal ultrasound

Fetal heart rate abnormality in labour · women with singleton cephalic fetuses undergoing assessment for pre‐induction cervical ripening.

Bishop score showed no clear difference in fetal heart rate abnormality in labour compared with transvaginal ultrasound; GRADE not reported.

1 finding from 1 review

Intervention not reported

ECG Abnormalities ‐ RCT data ‐ benznidazole · people with chronic asymptomatic Trypanosoma cruzi infection

The intervention showed no clear difference in ECG Abnormalities ‐ RCT data ‐ benznidazole (low certainty).

1 finding from 1 review

Intervention not reported

Child psychosocial development Parents reporting their child develops abnormally · children younger than five years of age and their families

It is very uncertain whether the intervention changes child psychosocial development Parents reporting their child… (very low certainty).

1 finding from 1 review