Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

291 questions · 293 findings · 75 reviews

No studies found 56 · 19.1%GRADE not reported 24 · 8.2%Very low 61 · 20.8%Low 62 · 21.2%Moderate 39 · 13.3%High 51 · 17.4%

Mefloquine vs doxycycline

Abnormal thoughts or perceptions · Non‐immune adults and children travelling to malaria‐endemic settings

Mefloquine showed no clear difference in abnormal thoughts or perceptions compared with doxycycline; GRADE not reported.

1 finding from 1 review

Deferasirox vs placebo

AE: abnormal serum creatinine (post‐baseline) · people with non‐transfusion‐dependent thalassemia

It is very uncertain whether deferasirox changes AE: abnormal serum creatinine (post‐baseline) compared with placebo (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ZIPRASIDONE

Adverse effects: Specific ‐ clinically significant abnormal ECG during 72 hours · psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes adverse effects: Specific ‐ clinically significant abnormal ECG… compared with OTHER ANTIPSYCHOTIC: j. ZIPRASIDONE (very low certainty).

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Aesthetics: canine rated as abnormal tooth colour · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in aesthetics: canine rated as abnormal tooth colour compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Corticosteroids vs placebo

Congenital abnormalities · Pregnant women with hyperemesis gravidarum

It is very uncertain whether corticosteroids changes congenital abnormalities compared with placebo (very low certainty).

1 finding from 1 review

Routine/revealed vs selective/concealed ultrasound

Detection of fetal abnormality before 24 weeks' gestation · Fetal ultrasound assessment before 24 weeks' gestation

Routine/revealed probably leads to higher detection of fetal abnormality before 24 weeks' gestation compared with selective/concealed ultrasound (moderate certainty).

1 finding from 1 review