White spot lesion development (QLF: mineral loss, lesion area/depth, new lesions) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)
A single RCT found the one-step adhesive without a primer (GC Ortho Connect) produced more and more severe white spot lesions than conventional multi-step systems (ungraded).
1 finding from 1 review
Dental caries · Adults from Japanese and European cohorts (present-study Japanese direct-to-consumer cohort + GLIDE consortium and UK Biobank European…
Meta-analysis identified a novel genome-wide-significant locus for dental caries at rs4801882 in SIGLEC5 (P=1.71E-08); ungraded.
1 finding from 1 review
d/D dft/DFT or dmft/DMFT score differences · Children and adults with primary or permanent dentition
Eight studies calculated caries-score differences; six reported no significant difference, one underestimation, and one overestimation with teledentistry.
1 finding from 1 review
no estimate extracted
8 studies
GRADE not reported
Periodontitis (clinical attachment loss) · Adults in case-control studies (oral cancer patients vs healthy controls)
Clinical attachment loss was significantly greater in oral cancer patients than controls (SMD 1.94, 95% CI 0.22-3.66), though heterogeneity was very high (I2=96.7%); ungraded.
1 finding from 1 review
Bracket (bond) failure · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Clearfil Protect Bond showed no difference in bracket failure, with certainty not graded.
1 finding from 1 review
No statistically significant difference in bond failure rates was observed between quadrants bonded with Clearfil (CF) and those bonded with the conventional primer (p = 0.316).
1 study · 35 participants
GRADE not reported
Intervention not reported
Dental caries (early childhood caries)
1 finding from 1 review
AOR 6.7
1 study
GRADE not reported
Dental caries prevalence · Nigerian individuals, including children and adults, with primary or permanent dentition
High-frequency sugar consumption was associated with 18% higher but non-significant odds of dental caries in Nigeria (OR 1.18, 95% CI 0.87 to 1.59; I2=36%; ungraded).
1 finding from 1 review
Bacterial adhesion · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; two included studies reported reduced Streptococcus mutans adhesion with grape seed extract or fractions.
1 finding from 1 review
no estimate extracted
2 studies
GRADE not reported
White spot lesion incidence · High caries-risk patients: fixed-orthodontic-appliance patients and children with partially erupted permanent molars
Low-power CO2 laser (LLLT) is associated with a lower incidence of new white spot lesions than placebo (OR 0.21, CI 0.15 to 0.30; ungraded, 3 RCTs, considerable heterogeneity I2=71%).
1 finding from 1 review
Intervention not reported
Overall success (composite of clinical and radiographic success)
1 finding from 1 review
Specificity for dental caries diagnosis · Children and adults with primary or permanent dentition
Specificity ranged from 83% to 100% across 13 studies; no meta-analysis or GRADE rating was reported.
1 finding from 1 review
no estimate extracted
13 studies
GRADE not reported
Enamel demineralization (DIAGNOdent score) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
TiO2-modified composite favored lower DIAGNOdent scores, with certainty not graded.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
Over-dominant model (CC+TT vs CT) at FokI(rs10735810) showed no significant association with caries (OR 0.83); ungraded.
1 finding from 1 review
Dental caries · Children (<18 years) with vs without dental caries
FokI(rs2228570) allelic model: A vs G was not significantly associated with dental caries (OR 1.07); ungraded.
1 finding from 1 review
Enamel acid resistance (cross-sectional microhardness) · Human enamel in pits and fissures (in situ / ex vivo)
Nd:YAG laser increased enamel acid resistance versus untreated enamel in pits and fissures (ungraded, 1 ex-vivo study, no pooled estimate).
1 finding from 1 review
Dental caries in children · Children aged 4 to 6 years whose mothers' prenatal vitamin D status was assessed
Among children aged 4-6 years, prenatal vitamin D deficiency is associated with significantly higher odds of dental caries (OR 1.44, 95% CI 1.32-1.56); ungraded.
1 finding from 1 review
Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesPrenatal exposure; dental caries at 4 to 6 years · Observational pregnancy/birth-cohort studies (one cross-sectional), mostly in developed countries (USA, Canada, Japan, Australia, Spain, Netherlands, Poland, New Zealand, Turkey) · Children's age subgroup: 4 to 6 years
OR 1.44 [1.32, 1.56]
8 studies
GRADE not reported
Antioxidant capacity · Streptococcus mutans (in vitro cultures and biofilms)
No meta-analysis was conducted; one included study reported antioxidant properties of cranberry fractions.
1 finding from 1 review
no estimate extracted
1 study
GRADE not reported
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF and ART/glass ionomer cement showed no clear difference in tooth-level caries arrestment (OR 1.22, wide CI; ungraded subgroup).
1 finding from 1 review
Calcium ions released in acidic solution · Human tooth enamel specimens, sound/intact (in vitro)
Er:YAG laser irradiation did not significantly change calcium ions released into acidic solution versus untreated control (SMD -0.40, 95% CI -0.96 to 0.15; 6 in vitro studies, I2=80%; ungraded).
1 finding from 1 review
Model development with reported performance measures (per CHARMS) · Individuals of any age at risk of caries increment
No original CAMBRA or CAT model-development studies reporting performance measures according to CHARMS were found (evidence gap); these tools appeared only as validated models within other studies.
1 finding from 1 review
no estimate extracted
0 studies
No studies found