Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,288 questions · 3,354 findings · 516 reviews · Headline outcomes only

No studies found 720 · 21.5%GRADE not reported 164 · 4.9%Very low 950 · 28.3%Low 932 · 27.8%Moderate 434 · 12.9%High 154 · 4.6%

Alarm vs other types of alarm

Proportion of children achieving 14 consecutive dry nights by the end of treatment · children with nocturnal enuresis

It is very uncertain whether alarm changes proportion of children achieving 14 consecutive dry nights by the… compared with other types of alarm (very low certainty).

1 finding from 1 review

Alarm vs miscellaneous treatments

Proportion of children achieving 14 consecutive dry nights by the end of treatment · children with nocturnal enuresis

It is very uncertain whether alarm changes proportion of children achieving 14 consecutive dry nights by the… compared with miscellaneous treatments (very low certainty).

1 finding from 1 review

Benznidazole vs placebo

Clinical improvement (N) (a) Heart failure (b) Sustained ventricular tachycardia · adults with both late‐stage, symptomatic Chagas disease and CCC

Benznidazole showed no clear difference in clinical improvement (N) (a) Heart failure (b) Sustained ventricular… compared with placebo (low certainty).

1 finding from 1 review

IVIg vs placebo or no treatment

Event‐free survival (no death, transplant, or left ventricular assist device) ‐ adults with myocarditis · adults with acute myocarditis

It is very uncertain whether intravenous immunoglobulin changes event‐free survival (risk of death, cardiac transplant, or left… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Corticosteroids vs placebo or no treatment

Intraventricular haemorrhage · infants born of women at risk of preterm birth

Neonatal and child outcomes: corticosteroids probably leads to lower intraventricular haemorrhage (IVH)№ of participants: 8475(12 RCTs) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Intervention not reported

Intraventricular haemorrhage (grades III and IV) · preterm infants with low birth weight

The intervention probably leads to lower intraventricular haemorrhage (grades III and IV) (moderate certainty).

1 finding from 1 review

Intervention not reported

Spherical aberration soft contact lenses vs single vision soft contact lenses · children with myopia (nearsightedness)
1 finding from 1 review

Intervention not reported

Cranial ultrasound abnormalities ‒intraventricular haemorrhage grade 3 to 4 · infants below 33 weeks of postmenstrual age who required resuscitation in the delivery room

It is very uncertain whether the intervention changes cranial ultrasound abnormalities ‒intraventricular haemorrhage grade… (very low certainty).

1 finding from 1 review