What do systematic reviews say?

Culturally adapted health literacy skills building course vs no/unrelated health literacy intervention

• Interventions for improving health literacy in migrants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 290 participants
  Very low

Culturally and literacy adapted self‐management programme vs no health literacy intervention

• Interventions for improving health literacy in migrants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 333 participants
  Moderate

Percutaneous nephrolithotomy vs retrograde intrarenal surgery

Percutaneous nephrolithotomy may leads to lower need for secondary interventions Assumed MCID: 5% compared with retrograde intrarenal surgery (low certainty).

• Percutaneous nephrolithotomy versus retrograde intrarenal surgery for treatment of renal stones in adults 2023 · Cochrane Headline outcomes only
  RR 0.31 [0.17, 0.55]
  21 studies · 2005 participants
  Low

Topical anesthetics vs placebo or no intervention

It is very uncertain whether topical anesthetics changes apnea: occurrence of one or more episodes№ of LPs: 100(1 quasi‐RCT) compared with placebo or no intervention (very low certainty).

• Pharmacological interventions for the management of pain and discomfort during lumbar puncture in newborn infants 2023 · Cochrane Headline outcomes only
  RR 3.24 [0.14, 77.79]
  Studies not reported
  Very low

Combined steroid and antibiotic therapy vs antibiotics alone

The review found no eligible studies for this question.

• Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (low certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  HR 1.06 [0.71, 1.60]
  1 study · 198 participants
  Low

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

Double primary (canine and first molar) tooth extraction showed no clear difference in incidence of successfully erupted PDC that were favourably positioned compared with single primary (canine) tooth extraction; GRADE not reported.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes

  24 months
  RR 1.64 [0.33, 8.03]
  1 study · 23 participants
  GRADE not reported
• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes

  12 months
  RR 1.09 [0.08, 15.42]
  1 study · 23 participants
  GRADE not reported
• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes

  18 months
  RR 1.64 [0.33, 8.03]
  1 study · 23 participants
  GRADE not reported

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Induction chemotherapy plus locoregional treatment (radiotherapy… showed no clear difference in overall survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone (moderate certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  HR 0.85 [0.70, 1.04]
  5 studies · 7427 participants
  Moderate

Induction chemotherapy plus locoregional treatment (radiotherapy and/or surgery) vs Locoregional treatment (radiotherapy and/or surgery) alone

Induction chemotherapy plus locoregional treatment (radiotherapy… led to lower disease-free survival, induction platinum + 5-fluorouracil prior to… compared with locoregional treatment (radiotherapy and/or surgery) alone; GRADE not reported.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  HR 0.78 [0.63, 0.97]
  3 studies · 332 participants
  GRADE not reported

Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Concomitant (concurrent) chemoradiotherapy led to lower locoregional control, concurrent chemoradiotherapy (platinum +… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  RR 0.75 [0.61, 0.93]
  3 studies
  GRADE not reported

Surgery +/- radiotherapy + (adjuvant) chemotherapy vs Surgery +/- radiotherapy alone (observation or adjuvant radiotherapy only)

Surgery +/- radiotherapy + (adjuvant) chemotherapy showed no clear difference in overall survival, adjuvant chemotherapy vs observation alone… compared with surgery +/- radiotherapy alone (observation or adjuvant radiotherapy… (moderate certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  HR 0.95 [0.73, 1.22]
  5 studies · 353 participants
  Moderate

Prism adaptation test with eye muscle surgery vs eye muscle surgery alone

The review found no eligible studies for this question.

• Interventions for intermittent exotropia 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Concomitant (concurrent) chemoradiotherapy led to lower disease-free survival, concurrent chemoradiotherapy vs radiotherapy… compared with radiotherapy alone (non-resectable tumours); GRADE not reported.

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  HR 0.74 [0.67, 0.80]
  13 studies
  GRADE not reported

Concomitant (concurrent) chemoradiotherapy vs Radiotherapy alone

Concomitant (concurrent) chemoradiotherapy probably leads to lower overall survival, concurrent chemoradiotherapy vs radiotherapy alone… compared with radiotherapy alone (non-resectable tumours) (moderate certainty).

• Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
  HR 0.74 [0.67, 0.83]
  24 studies · 2852 participants
  Moderate

Antimicrobial coolant A (chlorhexidine) vs povidone‐iodine

It is very uncertain whether antimicrobial coolant A (chlorhexidine) changes reduction in level of contamination in aerosols (CFU): chlorhexidine… compared with antimicrobial coolant B (povidone iodine) (very low certainty).

• Interventions to reduce contaminated aerosols produced during dental procedures for preventing infectious diseases 2020 · Cochrane All outcomes
  MD -59.30 [-64.16, -54.44]
  1 study · 20 participants
  Very low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

Summary of findings ‐ DVD plus information booklet showed no clear difference in compliance or adherence to the trial intervention (including… compared with information booklet alone (low certainty).

• Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
  RR 1.02 [0.81, 1.28]
  1 study · 108 participants
  Low

Summary of findings ‐ DVD plus information booklet vs information booklet alone

The review found no eligible studies for this question.

• Psychological interventions for people with hemophilia 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Bakri balloon tamponade vs condom‐loaded Foley Catheter (one intrauterine tamponade compared to another intrauterine tamponade technique)

The review found no eligible studies for this question.

• Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Bakri balloon tamponade+traction stitch vs Bakri balloon (one intrauterine tamponade compared to another intrauterine tamponade technique)

The review found no eligible studies for this question.

• Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

The review found no eligible studies for this question.

• Mechanical and surgical interventions for treating primary postpartum haemorrhage 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found