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What do systematic reviews say?

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Evidence found and GRADE certainty

2,262 questions · 2,405 findings · 248 reviews · Headline outcomes only

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No studies found 507 · 21.1%GRADE not reported 93 · 3.9%Very low 657 · 27.3%Low 708 · 29.4%Moderate 387 · 16.1%High 53 · 2.2%

Single foetal haemoglobin inducer at any dose or duration vs placebo or usual care

Adverse events · people with non‐transfusion‐dependent β‐thalassaemia

It is very uncertain whether single foetal haemoglobin inducer at any dose or duration changes adverse events compared with usual care or placebo (very low certainty).

1 finding from 1 review

Digital technology vs usual care

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adolescents and adults with cystic fibrosis

Digital technology showed no clear difference in number of pulmonary exacerbations: number of participants… compared with usual care (moderate certainty).

1 finding from 1 review

Digital technology vs usual care

New micro‐organisms: number of participants in whom new organisms are detected · adolescents and adults with cystic fibrosis

Digital technology probably leads to lower new micro‐organisms: number of participants in whom new organisms… compared with usual care (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

Summary of findings table ‐ Psychological interventions showed no clear difference in substance use ‐ post‐interventiong compared with inactive control (usual care care, attention control, waitlist) (low certainty).

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood
1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parental self‐harm ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Psychological interventions vs inactive control (usual care care, attention control, waitlist)

Parent‐child relationship or assessment of parenting · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

It is very uncertain whether summary of findings table ‐ Psychological interventions changes parent–child relationship ‐ post‐interventionm compared with inactive control (usual care care, attention control, waitlist) (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Trauma‐related symptoms ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Psychological well‐being (secondary outcome) Not addressed · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood
1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Substance use ‐ post‐intervention ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Service system approaches vs inactive control (usual care care, attention control, waitlist)

Parent relationship quality ‐ not reported · for parents who are experiencing CPTSD symptoms or have experienced maltreatment in their childhood

The review found no eligible studies for this question.

1 finding from 1 review