Local adverse effects ‐ lens opacity requiring cataract removal (unit of analysis: eyes) · preterm infants with type 1 ROP
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes local adverse effects ‐ lens opacity requiring cataract removal… compared with conventional laser/cryotherapy (very low certainty).
1 finding from 1 review
Recurrence of ROP (up to 6 months of age) · preterm infants with type 1 ROP
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes recurrence of ROP (up to 6 months of age) compared with conventional laser/cryotherapy (very low certainty).
1 finding from 1 review
Recurrence of ROP (unit of analysis: eyes) · preterm infants with type 1 ROP
It is very uncertain whether anti‐vascular endothelial growth factor therapy changes recurrence of ROP (unit of analysis: eyes) compared with conventional laser/cryotherapy (very low certainty).
1 finding from 1 review
Severe visual impairment or blindness at 6 to 12 months' corrected age · Prevention of retinopathy of prematurity in preterm infants
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Rescue treatment with anti‐VEGF agents · Prevention of retinopathy of prematurity in preterm infants
Systemic administration of beta‐blockers may leads to lower rescue treatment with anti‐VEGF agents compared with placebo or no treatment (low certainty).
1 finding from 1 review
Treatment with laser photocoagulation or cryotherapy · Prevention of retinopathy of prematurity in preterm infants
Systemic administration of beta‐blockers may leads to lower treatment with laser photocoagulation or cryotherapy compared with placebo or no treatment (low certainty).
1 finding from 1 review
Progression to stage 2 with plus disease · Prevention of retinopathy of prematurity in preterm infants
Systemic administration of beta‐blockers showed no clear difference in progression to stage 2 with plus disease compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Progression to stage 3 ROP · Prevention of retinopathy of prematurity in preterm infants
Systemic administration of beta‐blockers probably leads to lower progression to stage 3 ROP compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Progression to stage 4 or 5 ROP · Prevention of retinopathy of prematurity in preterm infants
Systemic administration of beta‐blockers showed no clear difference in progression to stage 4 or 5 ROP compared with placebo or no treatment (moderate certainty).
1 finding from 1 review
Arterial hypotension and/or bradycardia requiring treatment · Prevention of retinopathy of prematurity in preterm infants
Systemic administration of beta‐blockers may leads to higher arterial hypotension and/or bradycardia requiring treatment compared with placebo or no treatment (low certainty).
1 finding from 1 review
Necrotising enterocolitis · preterm infants
It is very uncertain whether oropharyngeal colostrum (OPC) changes incidence of necrotising enterocolitis (NEC) compared with control (water, saline, or no intervention) (very low certainty).
1 finding from 1 review
Any late‐onset sepsis ‐ all infants · preterm infants
It is very uncertain whether oropharyngeal colostrum (OPC) changes incidence of late‐onset sepsis compared with control (water, saline, or no intervention) (very low certainty).
1 finding from 1 review
Death of baby (up to discharge) · preterm infants
It is very uncertain whether oropharyngeal colostrum (OPC) changes death before discharge to home compared with control (water, saline, or no intervention) (very low certainty).
1 finding from 1 review
Time to achieve full enteral feeding (days) · preterm infants
1 finding from 1 review
Length of hospital stay · preterm infants
1 finding from 1 review
Pneumonia · preterm infants
Oropharyngeal colostrum (OPC) showed no clear difference in pneumonia compared with control (water, saline, or no intervention) (low certainty).
1 finding from 1 review
Reported adverse effects · preterm infants
1 finding from 1 review
Mortality ≤2 years after hospital discharge · preterm infants
Respiratory support showed no clear difference in mortality ≤2 years after hospital discharge compared with no respiratory support before cord clamping (low certainty).
1 finding from 1 review
RR 1.67 [0.41, 6.73]
150 participants
Low
Inotropic support for hypotension · preterm infants
Respiratory support showed no clear difference in inotropic support for hypotension compared with no respiratory support before cord clamping (low certainty).
1 finding from 1 review
RR 1.25 [0.63, 2.49]
150 participants
Low
Peak haematocrit · preterm infants
Respiratory support showed no clear difference in peak haematocrit compared with no respiratory support before cord clamping (moderate certainty).
1 finding from 1 review
MD 0.2
150 participants
Moderate