Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,163 questions · 1,209 findings · 133 reviews · Headline outcomes only

No studies found 176 · 14.6%GRADE not reported 47 · 3.9%Very low 241 · 19.9%Low 323 · 26.7%Moderate 315 · 26.1%High 107 · 8.9%

Intervention not reported

All‐cause mortality: up to 3 months' · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes all‐cause mortality: up to 3 months' (very low certainty).

1 finding from 1 review

Intervention not reported

Health‐related quality of life: up to 3 months ( · participants with alcoholic hepatitis at high risk of mortality and morbidity

The intervention showed no clear difference in health‐related quality of life: up to 3 months ( (low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events during treatment · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes serious adverse events during treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Liver‐related mortality: up to 3 months' · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes liver‐related mortality: up to 3 months' (very low certainty).

1 finding from 1 review

Intervention not reported

Participants with any complication: up to 3 months following randomisation · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes participants with any complication: up to 3 months following… (very low certainty).

1 finding from 1 review

Intervention not reported

Participants with non‐serious adverse events: up to 3 months' · participants with alcoholic hepatitis at high risk of mortality and morbidity

It is very uncertain whether the intervention changes participants with non‐serious adverse events: up to 3 months' (very low certainty).

1 finding from 1 review

Effects of different delivery devices on growth in children with persistent asthma: hydrofluoroalkane‐metered dose inhaler beclomethasone vs beclomethasone

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

Effects of different delivery devices on growth in children with… showed no clear difference in linear growth velocity (cm/year) compared with chlorofluorocarbon‐metered dose inhaler beclomethasone (low certainty).

1 finding from 1 review

Effects of different delivery devices on growth in children with persistent asthma: Easyhaler‐budesonide vs Turbuhaler‐budesonide

Change in height · children up to 18 years of age with persistent asthma

Effects of different delivery devices on growth in children with… may leads to higher change in height (cm) over a period of time compared with turbuhaler‐budesonide (low certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

All‐cause mortality Up to 28 days following admission · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

Number and nature of adverse events secondary to corticosteroid use (hospital‐acquired infection) · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number and nature of adverse events secondary to corticosteroid use… compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Mortality (all‐cause) · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes mortality (all‐cause) compared with once‐daily LAMA (very low certainty).

1 finding from 1 review

Once‐daily ICS/LABA combined inhalers vs once‐daily LAMA

Pneumonia · patients with chronic obstructive pulmonary disease

It is very uncertain whether once‐daily ICS/LABA combined inhalers changes pneumonia compared with once‐daily LAMA (very low certainty).

1 finding from 1 review