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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,280 questions in 114 reviews · Cystic Fibrosis and Genetic Disorders
current versionsNo studies 856 · 37.5%Ungraded 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Summary of findings ‐ Exercise A vs Exercise B Pain: reduction of pain intensity by visual analogue scale · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 27 participants | Low |
Summary of findings ‐ Exercise A vs Exercise B Functional Status: 6MWT (metres) · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 30 participants | Very low |
Summary of findings ‐ Exercise A vs Exercise B Range of Motion: flexion and extension · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 27 participants | Low |
Summary of findings ‐ Exercise A vs Exercise B Strength: flexors and extensors · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 3 studies · 90 participants | Moderate |
Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality Adverse events · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality Quality of life · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality Pain · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality Functional Status · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Exercise alone vs exercise plus electrophysical modality Joint health: Modified Colorado Score · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 25 participants | Very low |
Summary of findings ‐ Exercise vs no intervention Quality of life · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Hydrotherapy vs no exercise Adverse events · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Hydrotherapy vs no exercise Quality of life · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Hydrotherapy vs no exercise Pain · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Hydrotherapy vs no exercise Functional status · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Hydrotherapy vs no exercise Range of motion: flexion and extension · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 20 participants | Very low |
Summary of findings ‐ Hydrotherapy vs no exercise Strength: knee flexor and extensor strength · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 20 participants | Very low |
Summary of findings ‐ Exercise vs no intervention Joint health: Modified Colorado Score · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 25 participants | Low |
Summary of findings ‐ Exercise vs no intervention Pain: reduction of pain intensity by visual analogue scale · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 18 participants | Very low |
Summary of findings ‐ Exercise vs no intervention Functional Status · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Exercise vs no intervention Range of Motion: joint flexion and joint extension · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 18 participants | Very low |
Summary of findings ‐ Exercise vs no intervention Strength: bicep strength · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | 1 study · 18 participants | Very low |
Summary of findings ‐ Exercise A vs Exercise B Adverse events · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings ‐ Exercise A vs Exercise B Quality of life · participants with haemophilia Exercise for haemophilia (2016) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs placebo or standard care Frequency of transfusion · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs placebo or standard care Major adverse effects · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs placebo or standard care Quality of life · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | no estimate extracted | NR | No studies |
Hydroxyurea vs placebo or standard care Mean Hb F (g/dL) · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Frequency of transfusion · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Major adverse effects ‐ Neutropenia · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | RR 9.93 [1.34, 73.67] | 1 study · 61 participants | Very low |
Intervention NR Major adverse effects ‐ Thrombocytopenia · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | RR 3.68 [1.12, 12.07] | 1 study · 61 participants | Very low |
Intervention NR Quality of life · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Mean Hb F at 24 weeks (g/dL) · people with non‐transfusion dependent beta thalassaemia Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias (2016) · Cochrane | no estimate extracted | 1 study · 61 participants | Low |
Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo Change in weight in kg at 6 months · children with chronic disease Oral protein calorie supplementation for children with chronic disease (2015) · Cochrane | no estimate extracted | 3 studies · 125 participants | Moderate |
Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo Change in weight Z score at 6 months · children with chronic disease Oral protein calorie supplementation for children with chronic disease (2015) · Cochrane | no estimate extracted | 2 studies · 109 participants | High |
Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo Change in height in cm at 6 months · children with chronic disease Oral protein calorie supplementation for children with chronic disease (2015) · Cochrane | no estimate extracted | 2 studies · 109 participants | High |
Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo Change in BMI at 6 months · children with chronic disease Oral protein calorie supplementation for children with chronic disease (2015) · Cochrane | no estimate extracted | 2 studies · 109 participants | High |
Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo Change in total energy intake (kcal/day) at 3 months · children with chronic disease Oral protein calorie supplementation for children with chronic disease (2015) · Cochrane | no estimate extracted | 2 studies · 53 participants | High |
Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo Change in total protein intake (g/day) at 3 months · children with chronic disease Oral protein calorie supplementation for children with chronic disease (2015) · Cochrane | no estimate extracted | 2 studies · 53 participants | High |
Oral protein calorie supplements vs no intervention, placebo or additional nutritional advice compared to placebo Disease severity score: change in FEV1 % predicted at 12 months · children with chronic disease Oral protein calorie supplementation for children with chronic disease (2015) · Cochrane | no estimate extracted | 1 study · 70 participants | High |
Single vs combination IV antibiotics FEV1 (% predicted) absolute change · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | 6 studies · 265 participants | Low |
Oral antibiotics vs IV antibiotics Time to next exacerbation · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | NR | No studies |
Oral antibiotics vs IV antibiotics Quality of life · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | NR | No studies |
Single vs combination IV antibiotics FVC (% predicted) absolute change · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | 4 studies · 146 participants | Low |
Single vs combination IV antibiotics Time to next exacerbation (weeks) · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | 1 study · 34 participants | Low |
Single vs combination IV antibiotics Quality of life · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | NR | No studies |
Nebulised antibiotics vs IV antibiotics FVC (% predicted) absolute change · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | 1 study · 54 participants | Very low |
Nebulised antibiotics vs IV antibiotics Time to next exacerbation · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | NR | No studies |
Nebulised antibiotics vs IV antibiotics Quality of life · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | NR | No studies |
Oral antibiotics vs IV antibiotics FEV1 (% predicted) absolute change · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | 1 study · 24 participants | Low |
Oral antibiotics vs IV antibiotics FVC (% predicted) absolute change · people with cystic fibrosis experiencing a pulmonary exacerbation Intravenous antibiotics for pulmonary exacerbations in people with cystic fibrosis (2015) · Cochrane | no estimate extracted | 1 study · 24 participants | Low |