Cochrane · systematic review · CD011579
Hydroxyurea for reducing blood transfusion in non‐transfusion dependent beta thalassaemias
Foong, WC, Ho, JJ, Loh, CK, et al. · Cochrane Database of Systematic Reviews · 2016 · Cochrane Library
Cystic Fibrosis and Genetic DisordersAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
3
No studies
6
Included studies
NR
No studies 6 · 66.7%Ungraded 0 · 0%Very low 2 · 22.2%Low 1 · 11.1%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Hydroxyurea versus placebo or standard care for non‐transfusion dependent beta thalassaemia
Population: people with non‐transfusion dependent beta thalassaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of transfusion Hydroxyurea vs placebo or standard care | no estimate extracted | NR | No studies |
Major adverse effects Hydroxyurea vs placebo or standard care | no estimate extracted | NR | No studies |
Quality of life Hydroxyurea vs placebo or standard care | no estimate extracted | NR | No studies |
Mean Hb F (g/dL) Hydroxyurea vs placebo or standard care | no estimate extracted | NR | No studies |
Different doses or dose regimens of hydroxyurea compared
Population: people with non‐transfusion dependent beta thalassaemia
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Frequency of transfusion | no estimate extracted | NR | No studies |
Major adverse effects ‐ Neutropenia | RR 9.93 [1.34, 73.67] | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision |
Major adverse effects ‐ Thrombocytopenia | RR 3.68 [1.12, 12.07] | 1 study · 61 participants | Very low Downgraded: risk of bias, imprecision |
Quality of life | no estimate extracted | NR | No studies |
Mean Hb F at 24 weeks (g/dL) | no estimate extracted | 1 study · 61 participants | Low Downgraded: risk of bias |