Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,087 questions · 2,360 findings · 390 reviews

No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

CLOZAPINE + AMISULPIRIDE vs CLOZAPINE + QUETIAPINE (Genc 2007)

Leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + AMISULPIRIDE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + QUETIAPINE (Genc 2007) (very low certainty).

1 finding from 1 review

CLOZAPINE + RISPERIDONE vs CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + RISPERIDONE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + ZIPRASIDONE (Kuwilsky 2010) (very low certainty).

1 finding from 1 review

CLOZAPINE + ZIPRASIDONE vs CLOZAPINE + QUETIAPINE (Wen 2015)

Leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + ZIPRASIDONE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + QUETIAPINE (Wen 2015) (very low certainty).

1 finding from 1 review

CLOZAPINE + ARIPIPRAZOLE vs CLOZAPINE + HALOPERIDOL (Cipriani 2013)

Acceptability of treatment ‐ leaving the study early · people with treatment‐resistant schizophrenia

It is very uncertain whether CLOZAPINE + ARIPIPRAZOLE changes leaving the study early: acceptability of treatment ‐ as measured by… compared with CLOZAPINE + HALOPERIDOL (Cipriani 2013) (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ adults · people with community‐acquired pneumonia

Corticosteroids probably leads to lower early clinical failure ‐ adults compared with control (moderate certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ adults ‐ severe CAP · people with community‐acquired pneumonia

Corticosteroids leads to lower early clinical failure ‐ adults ‐ severe CAP compared with control (high certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ adults ‐ non‐severe CAP · people with community‐acquired pneumonia

Corticosteroids leads to lower early clinical failure ‐ adults ‐ non‐severe CAP compared with control (high certainty).

1 finding from 1 review

Corticosteroids vs control

Early clinical failure ‐ children · people with community‐acquired pneumonia

Corticosteroids leads to lower early clinical failure ‐ children compared with control (high certainty).

1 finding from 1 review

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) vs HIGH DOSE (> 800 mg/day ‐ all medium term)

Behaviour: deterioration of behaviour (categorised as reason to leave early) · schizophrenia

CHLORPROMAZINE LOW DOSE (≤ 400 mg/day) may leads to higher behaviour: deterioration of behaviour (categorised as reason to… compared with HIGH DOSE (> 800 mg/day ‐ all medium term) (low certainty).

1 finding from 1 review

One‐incision vs two‐incision techniques

IKDC knee examination grade normal (grade A) or nearly normal (grade B) ‐ Intermediate/long‐term · adults undergoing arthroscopically assisted ACL reconstruction1

It is very uncertain whether one‐incision changes objective functional knee assessments using IKDC10 (intermediate… compared with two‐incision techniques (very low certainty).

1 finding from 1 review