What do systematic reviews say?

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Benefits and harms of CSF plus antibiotics showed no clear difference in infection‐related mortality compared with antibiotics alone (low certainty).

• Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
  RR 0.75 [0.47, 1.2]
  10 studies · 897 participants
  Low

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Benefits and harms of CSF plus antibiotics may leads to lower people hospitalized for > 10 days compared with antibiotics alone (low certainty).

• Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
  RR 0.65 [0.44, 0.95]
  7 studies · 1087 participants
  Low

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Benefits and harms of CSF plus antibiotics showed no clear difference in time to recovery from fever (lower values signify better outcomes) compared with antibiotics alone (low certainty).

• Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 966 participants
  Low

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Benefits and harms of CSF plus antibiotics showed no clear difference in time to withdrawal from ATB (lower values signify better outcomes) compared with antibiotics alone (low certainty).

• Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 457 participants
  Low

Benefits and harms of CSF plus antibiotics vs antibiotics alone

Benefits and harms of CSF plus antibiotics showed no clear difference in deep vein thrombosis compared with antibiotics alone (low certainty).

• Colony‐stimulating factors for chemotherapy‐induced febrile neutropenia 2014 · Cochrane Headline outcomes only
  RR 1.68 [0.72, 3.93]
  4 studies · 389 participants
  Low

Laparoscopic myomectomy vs open myomectomy (all types)

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 148 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 232 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 80 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; unscheduled return to… compared with open myomectomy (all types) (low certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 3.04 [0.12, 75.86]
  2 studies · 188 participants
  Low

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; laparoconversion compared with open myomectomy (all types) (moderate certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 1.11 [0.44, 2.83]
  8 studies · 756 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy showed no clear difference in perioperative in‐hospital adverse events; injury to pelvic organs compared with open myomectomy (all types) (moderate certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 3.04 [0.12, 75.86]
  1 study · 148 participants
  Moderate

Laparoscopic myomectomy vs open myomectomy (all types)

Laparoscopic myomectomy probably leads to lower in‐hospital adverse events; postoperative fever compared with open myomectomy (all types) (moderate certainty).

• Minimally invasive surgical techniques versus open myomectomy for uterine fibroids 2014 · Cochrane Headline outcomes only
  OR 0.44 [0.26, 0.77]
  6 studies · 635 participants
  Moderate

Laparoscopic vs open total mesorectal excision

Laparoscopic showed no clear difference in disease‐free survival at 5 years compared with open total mesorectal excision (moderate certainty).

• Laparoscopic versus open total mesorectal excision for rectal cancer 2014 · Cochrane Headline outcomes only
  OR 1.02 [0.76, 1.38]
  4 studies · 943 participants
  Moderate

Laparoscopic vs open total mesorectal excision

Laparoscopic showed no clear difference in overall survival at 5 years compared with open total mesorectal excision (moderate certainty).

• Laparoscopic versus open total mesorectal excision for rectal cancer 2014 · Cochrane Headline outcomes only
  OR 1.15 [0.87, 1.52]
  4 studies · 987 participants
  Moderate

Laparoscopic vs open total mesorectal excision

Laparoscopic showed no clear difference in local recurrences compared with open total mesorectal excision (moderate certainty).

• Laparoscopic versus open total mesorectal excision for rectal cancer 2014 · Cochrane Headline outcomes only
  OR 0.89 [0.57, 1.39]
  8 studies · 1538 participants
  Moderate

Laparoscopic vs open total mesorectal excision

• Laparoscopic versus open total mesorectal excision for rectal cancer 2014 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 3682 participants
  High

Laparoscopic vs open total mesorectal excision

Laparoscopic showed no clear difference in CRM positivity compared with open total mesorectal excision (moderate certainty).

• Laparoscopic versus open total mesorectal excision for rectal cancer 2014 · Cochrane Headline outcomes only
  OR 0.99 [0.71, 1.4]
  8 studies · 2313 participants
  Moderate

Laparoscopic vs open total mesorectal excision

Laparoscopic showed no clear difference in 30‐day morbidity (total) compared with open total mesorectal excision (moderate certainty).

• Laparoscopic versus open total mesorectal excision for rectal cancer 2014 · Cochrane Headline outcomes only
  OR 0.94 [0.8, 1.1]
  11 studies · 3397 participants
  Moderate

Laparoscopic vs open total mesorectal excision

• Laparoscopic versus open total mesorectal excision for rectal cancer 2014 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 3084 participants
  Moderate

Frankel's function regulator-4 (FR-4) with lip-seal training vs no treatment

The review found no eligible studies for this question.

• Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes
  Outcome proposed in the review but not found in any included study. The review states: 'The other outcomes proposed in this review were not found: stability of anterior open bite correction; reduction of snoring; signs…
  0 studies
  No studies found