Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

929 questions · 946 findings · 295 reviews · Headline outcomes only

No studies found 150 · 15.9%GRADE not reported 47 · 5%Very low 312 · 33%Low 262 · 27.7%Moderate 138 · 14.6%High 37 · 3.9%

Antibiotics vs placebo

All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Fewer vs more courses of chemotherapy (with or without radiotherapy

Secondary malignant neoplasms · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in secondary malignant neoplasms compared with more courses of chemotherapy (with or without radiotherapy (moderate certainty).

1 finding from 1 review

Fewer vs more courses of chemotherapy (with or without radiotherapy

Death · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in death compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

1 finding from 1 review

Fewer vs more courses of chemotherapy (with or without radiotherapy

Progression/relapse · Patients with untreated Hodgkin lymphoma (early stages)

Fewer showed no clear difference in progression/relapse compared with more courses of chemotherapy (with or without radiotherapy (high certainty).

1 finding from 1 review

Intervention not reported

Pain intensity (VAS) short term · patients with chronic mechanical neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Disability (neck and pain disability scale) short term · patients with chronic neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Quality of life (SF‐36 mental score) short term · patients with chronic neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Disability (NPQ) short term · patients with chronic mechanical neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Disability (NDI) short term · patients with chronic mechanical neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Quality of life (SF‐36) short term · patients with chronic mechanical neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Pain intensity (VAS) short term · patients with chronic neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Pain pressure threshold short term · patients with chronic neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Disability (NDI) short term Function (NPQ) short term · patients with chronic neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Quality of life (SF‐36, Functional Component) short term · patients with chronic neck pain (pain for more than 90 days)
1 finding from 1 review

Intervention not reported

Pain intensity (VAS) short term · patients with chronic neck pain (pain for more than 90 days)
1 finding from 1 review

Decompressive surgery plus radiotherapy vs radiotherapy

Ambulation · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…

Decompressive surgery plus radiotherapy may leads to higher ambulation Immediately after completing RT compared with radiotherapy (low certainty).

1 finding from 1 review

Decompressive surgery plus radiotherapy vs radiotherapy

Survival (short term) At 30 days · adults with metastatic extradural spinal cord compression (fit for surgery, paraplegic less than 48 hours, and without multiple discrete…

Decompressive surgery plus radiotherapy showed no clear difference in survival (short term) At 30 days compared with radiotherapy (low certainty).

1 finding from 1 review