Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Tranexamic acid vs placebo (saline solution or sterile water)

Postoperative bleeding (place of packing or revision surgery within 14 days of surgery) · adults and children with chronic rhinosinusitis with or without nasal polyps

Tranexamic acid showed no clear difference in postoperative bleeding (place of packing or revision surgery within… compared with placebo (saline solution or sterile water) (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Neonatal mortality · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Prehabilitation vs no prehabilitation

Complications within 30 days postoperatively · Patients with outcomes after colorectal cancer surgery

Prehabilitation showed no clear difference in complications within 30 days postoperatively compared with no prehabilitation (low certainty).

1 finding from 1 review

Two per cent CHG vs alcohol hand sanitiser (61% alcohol and emollients)

Incidence of bacteriologically confirmed infection (types of infection as specified by study authors) within the first 28 days of life ‐ all infections · Neonates and caregivers

Two per cent CHG probably leads to lower incidence of bacteriologically confirmed infections (types of… compared with alcohol hand sanitiser (61% alcohol and emollients) (moderate certainty).

1 finding from 1 review

Alcohol‐based handrub vs usual care

Incidence of (study author‐defined) suspected infection within the first 28 days of life · Neonates and caregivers

It is very uncertain whether alcohol‐based handrub changes incidence of suspected infections (author‐defined) within the first… compared with usual care (very low certainty).

1 finding from 1 review