Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,018 questions · 3,100 findings · 369 reviews · Headline outcomes only

No studies found 774 · 25%GRADE not reported 108 · 3.5%Very low 727 · 23.5%Low 840 · 27.1%Moderate 474 · 15.3%High 177 · 5.7%

Non‐pharmaceutical interventions vs control

Final visual acuity between 20/20 and 20/50; monocular vs binocular eye patching · people with traumatic hyphema

Non‐pharmaceutical interventions showed no clear difference in final visual acuity between 20/20 and 20/50; monocular vs binocular… compared with control (low certainty).

1 finding from 1 review

Non‐pharmaceutical interventions vs control

Risk of secondary hemorrhage; monocular versus binocular eye patching · people with traumatic hyphema

Non‐pharmaceutical interventions showed no clear difference in risk of secondary hemorrhage; monocular vs binocular eye patching compared with control (low certainty).

1 finding from 1 review

Botulinum toxin vs surgery

Proportion of participants who achieved binocular single vision at 6 or 12 months · adults and children with strabismus

Botulinum toxin showed no clear difference in proportion of participants who achieved binocular single vision at 6… compared with surgery (low certainty).

1 finding from 1 review

Application of heat vs application of cold

Adverse events due to treatment Minor adverse events, reported in studies as: exacerbation in pain after treatment; burn as a result of hot‐water immersion, or transient erythema, or adverse effects due to application of ice · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes adverse events due to treatment Minor adverse events, reported in… compared with application of cold (very low certainty).

1 finding from 1 review

Superoxide dismutase (SOD) vs placebo

Severe retinopathy of prematurity (stage II or greater)№ of participants: 244(1 RCT) · preterm infants at risk for bronchopulmonary dysplasia

It is very uncertain whether superoxide dismutase (SOD) changes severe retinopathy of prematurity (stage II or greater)№ of… compared with placebo (very low certainty).

1 finding from 1 review

Effect of GnRHas vs other hormonal treatment on bone mineral density

GnRHas vs gestrinone Percentage change values ‐ 12 months · Women with endometriosis, treated with GnRHas with effect on bone mineral density
2 findings from 1 review