Findings

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Evidence found and GRADE certainty

4,749 questions · 14,273 findings · 834 reviews

No studies found 3,655 · 25.6%GRADE not reported 2,115 · 14.8%Very low 3,646 · 25.5%Low 3,034 · 21.3%Moderate 1,503 · 10.5%High 320 · 2.2%

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Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

Mother microbiological presence (mutans streptococci colonisation level, CFU/mL) · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

Consumption of xylitol chewing gum by women (mothers) led to higher mother microbiological presence (mutans streptococci colonisation… compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to…; GRADE not reported.

1 finding from 1 review

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

defs index score · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

It is very uncertain whether consumption of xylitol chewing gum by women (mothers) changes defs index score (categories) compared with consumption of CHX/xylitol gum by women, or CHX varnish applied to… (very low certainty).

2 findings from 1 review

Consumption of xylitol chewing gum by women (mothers) vs Consumption of CHX/xylitol gum by women, or CHX varnish applied to women's dentition

Dental caries · For interventions, pregnant women and mothers of infants in the first year of life; for outcomes, children up to 6 years of age

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Risk for at least one adverse drug reaction (ADR) per participant · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ondansetron vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

It is very uncertain whether summary of findings table ‐ Ondansetron changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Topical capsaicin may leads to higher risk for at least one adverse event per patient compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifampin/rifampicin vs placebo

Risk for at least one adverse event per patient · participants with cholestatic pruritus (CP)

It is very uncertain whether summary of findings table ‐ Rifampin/rifampicin changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review

Enalapril ointment vs placebo

Change in burn‐related pruritus (VAS) ( · people with postburn pruritus

Enalapril ointment showed no clear difference in change in burn‐related pruritus (Scoring table for itching) ( compared with placebo (moderate certainty).

1 finding from 1 review

Massage vs usual care

Pain VAS for pain ( · people with postburn pruritus

Massage therapy showed no clear difference in pain VAS for pain ( compared with standard care (low certainty).

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Surgery for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes surgery for recurrent or persistent disease compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review

Surgery vs preoperative pharmacological therapy and surgery

Non‐surgical therapy for recurrent or persistent diseaseRadiation therapy and/or pharmacologic therapy for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas

It is very uncertain whether surgery alone changes non‐surgical therapy for recurrent or persistent diseaseRadiation… compared with preoperative pharmacological therapy and surgery (very low certainty).

1 finding from 1 review