Surgery vs preoperative pharmacological therapy and surgery: Surgery for recurrent or persistent disease
- Population
- adults with growth‐hormone secreting pituitary adenomas
- Intervention
- Surgery
- Comparison
- preoperative pharmacological therapy and surgery
- Outcome
- Surgery for recurrent or persistent disease
It is very uncertain whether surgery alone changes surgery for recurrent or persistent disease compared with preoperative pharmacological therapy and surgery (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Surgery alone vs preoperative pharmacological therapy and surgery Surgery for recurrent or persistent disease · adults with growth‐hormone secreting pituitary adenomas It is very uncertain whether surgery alone changes surgery for recurrent or persistent disease compared with preoperative pharmacological therapy and surgery (very low certainty). Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting… (2024) · Cochrane Headline outcomes only | RR 0.48 [0.05, 5.06] | 1 study · 61 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Surgical and non‐surgical interventions for primary and salvage treatment of growth hormone‐secreting pituitary adenomas in adults 2024 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Surgery vs Pharmacological therapy · adults with growth‐hormone secreting pituitary adenomas · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.