Intervention not reported
Inhibition of mixed-species S. mutans-C. albicans biofilm and C. albicans virulence-gene (HWP1/ALS1/ALS3) downregulation
1 finding from 1 review
- no estimate extracted1 studyGRADE not reported
Findings
What do systematic reviews say?
828 questions · 1,477 findings · 103 reviews
No studies found 5 · 0.3%GRADE not reported 1,402 · 94.9%Very low 38 · 2.6%Low 20 · 1.4%Moderate 11 · 0.7%High 1 · 0.1%
Intervention not reported
Osteoporosis
The intervention led to higher osteoporosis; GRADE not reported.
1 finding from 1 review
- From teeth to bone: dental caries has causal effects on osteoporosis and osteoporotic fracture. 2025 All outcomesDMFS, bias-corrected (MR-RAPS/Debiased IVW)OR 1.171 [1.051, 1.304]Studies not reportedGRADE not reported
Intervention not reported
Sensitivity
1 finding from 1 review
- Examining the diagnostic accuracy of artificial intelligence for detecting dental caries across a range of imaging… 2025 All outcomesImaging modality: Bitewing radiographsSensitivity 0.81 [0.72, 0.91]5 studiesGRADE not reported
Intervention not reported
Altered cariogenic-biofilm composition/architecture with reduced abundance of cariogenic species
1 finding from 1 review
- Postbiotics and Dental Caries: A Systematic Review. 2025 All outcomesIn vitro (multispecies biofilm)no estimate extracted1 studyGRADE not reported
Postbiotic toothpaste vs Fluoride toothpaste alone
Salivary immunoglobulin A and pH · children aged 6 to 12 years
No meta-analysis was conducted; postbiotic toothpaste was reported to increase salivary immunoglobulin A and pH versus fluoride toothpaste.
1 finding from 1 review
- no estimate extracted1 studyGRADE not reported
Intervention not reported
Specificity
1 finding from 1 review
- Examining the diagnostic accuracy of artificial intelligence for detecting dental caries across a range of imaging… 2025 All outcomesImaging modality: Bitewing radiographsSpecificity 0.89 [0.84, 0.95]5 studiesGRADE not reported
Not applicable (single-group prevalence) vs Not applicable
Prenatal vitamin D deficiency prevalence · pregnant women
The review reported a pooled prenatal vitamin D deficiency prevalence of 32%.
1 finding from 1 review
- Association between prenatal vitamin D deficiency with dental caries in infants and children: a systematic review and… 2024 All outcomesPregnancy · Mostly developed countries (Europe and America) · OverallProportion 0.32Studies not reportedGRADE not reported
Salivary Actinobacillus level vs Not specified
Salivary S. mutans level · Patients with aggressive periodontitis
Salivary Actinobacillus and S. mutans levels were negatively associated.
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesOverallOR 0.08 [0.01, 0.85]1 studyGRADE not reported
Periodontitis vs No periodontitis (periodontal health or gingivitis)
Mean DMFT (decayed, missing, filled teeth) · adults
Patients with periodontitis had a non-significantly higher mean DMFT (WMD 0.87).
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesPopulation-based and clinical dental study samples; multiple countries (1994-2022) · OverallWMD 0.87 [-0.03, 1.76]4 studiesGRADE not reported
Reduction in previous year's academic score vs No reduction in academic score
Reduction in previous year's academic score · Primary school children in Ethiopia
Dental caries was associated with higher odds of a reduction in the previous year's academic score (OR 5.51, 95% CI 1.952-9.066; ungraded).
1 finding from 1 review
- Prevalence of dental caries and associated factors among primary school children in Ethiopia: systematic review and… 2024 All outcomesSchools; Ethiopia (Addis Ababa, Bahir Dar, Finote Selam, Harer, Debre Birhan, North Showa)OR 5.51 [1.952, 9.066]Studies not reportedGRADE not reported
Genome-wide common variants (additive dosage; present-study GWAS) vs Genome-wide significance threshold (P<5E-8)
Periodontal disease - genome-wide-significant loci (present study) · Japanese adults (present-study cohort)
The present Japanese GWAS found no genome-wide-significant loci for periodontal disease (top suggestive rs12624579/SYNDIG1); ungraded.
1 finding from 1 review
- Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · Present-study GWAS (Japanese)In the present Japanese GWAS, no loci reached genome-wide significance for periodontal disease; several loci reached the suggestive level (P<1E-5). Top-associated variant rs12624579 (SYNDIG1 intron).1 study · 45525 participantsGRADE not reported
High salivary S. mutans level vs Lower salivary S. mutans level
Sites with attachment loss greater than 3 mm · Humans with salivary S. mutans measured
High salivary S. mutans was not associated with a clear difference in sites with attachment loss greater than 3 mm.
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesOverallOR 0.74 [0.35, 1.60]1 studyGRADE not reported
Salivary Actinobacillus level (high) vs Not specified
Salivary S. mutans level · Humans with salivary bacteria measured
Salivary F. nucleatum and Actinobacillus levels were not associated with a clear difference.
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesOverallOR 2.39 [1.00, 5.71]1 studyGRADE not reported
Periodontitis vs No periodontitis (periodontal health or gingivitis)
High salivary P. gingivalis (over 10^4 CFU/ml) · adults
Periodontitis was associated with higher odds of detectable high-level salivary P. gingivalis (OR 3.38).
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesSalivary/plaque microbiology samples from case-control studies · OverallOR 3.38 [1.46, 7.83]2 studiesGRADE not reported
Intervention not reported
Decayed, missing, filled surfaces (DMFS)
The intervention showed no clear difference in decayed, missing, filled surfaces (DMFS); GRADE not reported.
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesPercentage of sites with CAL >=3 mm (tertiles); single study (Robert 2019); adjustedOR 1.03 [1.00, 1.05]1 studyGRADE not reported
Genome-wide common variants (aggregate additive; LD score regression) vs Not applicable (variance-component estimate)
Periodontal disease - SNP-based heritability · Japanese adults (present-study cohort)
SNP-based heritability of periodontal disease was low (h2=0.0519, SE 0.0182); ungraded.
1 finding from 1 review
- Genome-wide association meta-analysis identifies two novel loci associated with dental caries. 2024 All outcomesLifelong (germline genotype) · Population-based genetic association study (Japanese direct-to-consumer genetic testing cohort) · LDSC heritability (present study)h2 (observed-scale SNP heritability) 0.05191 study · 45525 participantsGRADE not reported
Intervention not reported
Decayed surfaces (DS)
The intervention showed no clear difference in decayed surfaces (DS); GRADE not reported.
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesPercentage of sites with CAL >=3 mm (tertiles); single study (Robert 2019); adjustedOR 1.12 [1.00, 1.25]1 studyGRADE not reported
Salivary F. nucleatum level vs Not specified
Salivary S. mutans level · Humans with salivary bacteria measured
Salivary F. nucleatum and S. mutans levels were positively associated.
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesOverallOR 6.03 [1.55, 23.45]1 studyGRADE not reported
Intervention not reported
Decayed surfaces (DS)
The intervention led to higher decayed surfaces (DS); GRADE not reported.
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesPeriodontal disease severity (CDC-AAP); single study (Robert 2019); adjustedOR 1.18 [1.05, 1.32]1 studyGRADE not reported
Periodontitis vs No periodontitis (periodontal health or gingivitis)
High salivary S. mutans (over 10^4 CFU/ml) · adults
Salivary S. mutans showed a non-significant declining trend with periodontitis (OR 0.82).
1 finding from 1 review
- Association between periodontitis and dental caries: a systematic review and meta-analysis. 2024 All outcomesSalivary/plaque microbiology samples from case-control studies · OverallOR 0.82 [0.44, 1.51]2 studiesGRADE not reported