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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

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Review versions

1,248 questions in 108 reviews · Stroke

current versions

No studies 275 · 22%Ungraded 56 · 4.5%Very low 269 · 21.6%Low 349 · 28%Moderate 216 · 17.3%High 83 · 6.7%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone Successful reperfusion (mTICI 2b to 3) postprocedure · people with acute ischemic stroke Different types of percutaneous endovascular interventions for acute ischemic stroke (2023) · Cochrane	RR 1.01 [0.95, 1.07]	2 studies · 650 participants	High
Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone All‐cause mortality within 3 months · people with acute ischemic stroke Different types of percutaneous endovascular interventions for acute ischemic stroke (2023) · Cochrane	RR 1.01 [0.74, 1.37]	2 studies · 633 participants	High
Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone Intracranial hemorrhage on imaging at 24 hours · people with acute ischemic stroke Different types of percutaneous endovascular interventions for acute ischemic stroke (2023) · Cochrane	RR 1.03 [0.86, 1.24]	2 studies · 645 participants	High
Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone Symptomatic intracranial hemorrhage at 24 hours · people with acute ischemic stroke Different types of percutaneous endovascular interventions for acute ischemic stroke (2023) · Cochrane	RR 0.9 [0.49, 1.68]	2 studies · 645 participants	High
Thrombo‐aspiration alone vs stent‐retrieval thrombectomy alone Procedure‐related adverse events within 3 months · people with acute ischemic stroke Different types of percutaneous endovascular interventions for acute ischemic stroke (2023) · Cochrane	RR 0.98 [0.68, 1.41]	2 studies · 651 participants	High
Intervention NR Clinical HINTS Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	12 studies · 1890 participants	Low
Intervention NR Investigation of heterogeneity and sensitivity analyses Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	95 participants	Moderate
Intervention NR Conclusions Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	94 participants	Ungraded
Intervention NR Video‐assisted HINTS Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	3 studies · 199 participants	Very low
Intervention NR Clinical HINTS Plus Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	5 studies · 451 participants	Low
Intervention NR Video‐assisted HINTS Plus Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	2 studies · 163 participants	Moderate
Intervention NR Secondary objectives for HINTS subcomponents Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	NR	No studies
Intervention NR Head impulse Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	9 studies · 905 participants	Low
Intervention NR Video head impulse Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	3 studies · 239 participants	Very low
Intervention NR Nystagmus Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	9 studies · 1128 participants	Moderate
Intervention NR Test of skew Head impulse, nystagmus, and test of skew examination for diagnosing central causes of acute vestibular… (2023) · Cochrane	no estimate extracted	10 studies · 1313 participants	Moderate
Antiplatelet drug vs control Death or dependence at end of · acute ischaemic stroke Oral antiplatelet therapy for acute ischaemic stroke (2022) · Cochrane	Peto OR 0.95 [0.91, 0.99]	7 studies · 42034 participants	Moderate
Antiplatelet drug vs control Death from any cause during · acute ischaemic stroke Oral antiplatelet therapy for acute ischaemic stroke (2022) · Cochrane	Peto OR 0.93 [0.87, 0.98]	10 studies · 41929 participants	Very low
Antiplatelet drug vs control Pulmonary embolism during treatment period · acute ischaemic stroke Oral antiplatelet therapy for acute ischaemic stroke (2022) · Cochrane	Peto OR 0.71 [0.53, 0.96]	7 studies · 41042 participants	Very low
Antiplatelet drug vs control Recurrent ischaemic/unknown stroke during treatment period · acute ischaemic stroke Oral antiplatelet therapy for acute ischaemic stroke (2022) · Cochrane	Peto OR 0.79 [0.7, 0.88]	9 studies · 41652 participants	Very low
Antiplatelet drug vs control Symptomatic intracranial haemorrhage during treatment period · acute ischaemic stroke Oral antiplatelet therapy for acute ischaemic stroke (2022) · Cochrane	Peto OR 1.18 [0.97, 1.44]	9 studies · 41652 participants	Very low
Antiplatelet drug vs control Major extracranial haemorrhage during treatment period · acute ischaemic stroke Oral antiplatelet therapy for acute ischaemic stroke (2022) · Cochrane	Peto OR 1.69 [1.35, 2.11]	7 studies · 41042 participants	Very low
Antiplatelet drug vs control Complete recovery from stroke (post hoc) · acute ischaemic stroke Oral antiplatelet therapy for acute ischaemic stroke (2022) · Cochrane	Peto OR 1.06 [1.01, 1.11]	2 studies · 40541 participants	Moderate
Main comparison of patch angioplasty vs primary closure Any stroke (fatal or non‐fatal; contralateral, ipsilateral or brainstem; haemorrhage or infarct) within 30 days of operation · people undergoing carotid endarterectomy, whether initial indication for endarterectomy was symptomatic or… Patch angioplasty versus primary closure for carotid endarterectomy (2022) · Cochrane	OR 0.57 [0.31, 1.03]	8 studies · 1769 participants	Very low
Main comparison of patch angioplasty vs primary closure Ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct) within 30 days of operation · people undergoing carotid endarterectomy, whether initial indication for endarterectomy was symptomatic or… Patch angioplasty versus primary closure for carotid endarterectomy (2022) · Cochrane	OR 0.31 [0.15, 0.63]	7 studies · 1201 participants	Very low
Main comparison of patch angioplasty vs primary closure Occlusion of the operated artery within 30 days of operation · people undergoing carotid endarterectomy, whether initial indication for endarterectomy was symptomatic or… Patch angioplasty versus primary closure for carotid endarterectomy (2022) · Cochrane	OR 0.18 [0.08, 0.41]	7 studies · 1435 participants	Low
Main comparison of patch angioplasty vs primary closure Any stroke (fatal or non‐fatal; contralateral, ipsilateral or brainstem; haemorrhage or infarct) during long‐term · people undergoing carotid endarterectomy, whether initial indication for endarterectomy was symptomatic or… Patch angioplasty versus primary closure for carotid endarterectomy (2022) · Cochrane	OR 0.49 [0.27, 0.9]	7 studies · 1332 participants	Very low
Main comparison of patch angioplasty vs primary closure Ipsilateral stroke (fatal or non‐fatal; haemorrhage or infarct) during long‐term · people undergoing carotid endarterectomy, whether initial indication for endarterectomy was symptomatic or… Patch angioplasty versus primary closure for carotid endarterectomy (2022) · Cochrane	OR 0.32 [0.16, 0.63]	6 studies · 1141 participants	Very low
Main comparison of patch angioplasty vs primary closure Any stroke or death during long‐term · people undergoing carotid endarterectomy, whether initial indication for endarterectomy was symptomatic or… Patch angioplasty versus primary closure for carotid endarterectomy (2022) · Cochrane	OR 0.59 [0.42, 0.84]	6 studies · 1019 participants	Very low
Main comparison of patch angioplasty vs primary closure Restenosis (> 50%) or occlusion of operated artery during long‐term · people undergoing carotid endarterectomy, whether initial indication for endarterectomy was symptomatic or… Patch angioplasty versus primary closure for carotid endarterectomy (2022) · Cochrane	OR 0.24 [0.17, 0.34]	8 studies · 1719 participants	Low
Shunting vs no shunting Death from all causes within 30 days of surgery · patients with symptomatic or asymptomatic carotid disease Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring… (2022) · Cochrane	OR 0.45 [0.13, 1.59]	3 studies · 655 participants	Low
Shunting vs no shunting Stroke‐related death within 30 days of surgery (best‐case) · patients with symptomatic or asymptomatic carotid disease Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring… (2022) · Cochrane	OR 0.13 [0.02, 0.96]	3 studies · 655 participants	Low
Shunting vs no shunting Stroke‐related death within 30 days of surgery (worst‐case) · patients with symptomatic or asymptomatic carotid disease Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring… (2022) · Cochrane	OR 0.37 [0.05, 2.62]	3 studies · 655 participants	Low
Shunting vs no shunting Any stroke during surgery (best‐case) · patients with symptomatic or asymptomatic carotid disease Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring… (2022) · Cochrane	OR 0.42 [0.16, 1.07]	3 studies · 655 participants	Low
Shunting vs no shunting Any stroke during surgery (worst‐case) · patients with symptomatic or asymptomatic carotid disease Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring… (2022) · Cochrane	OR 1.32 [0.52, 3.38]	3 studies · 655 participants	Low
Shunting vs no shunting Any stroke within 24 hours of surgery · patients with symptomatic or asymptomatic carotid disease Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring… (2022) · Cochrane	OR 0.15 [0.03, 0.78]	2 studies · 214 participants	Low
Shunting vs no shunting Any stroke within 30 days of surgery · patients with symptomatic or asymptomatic carotid disease Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring… (2022) · Cochrane	OR 0.77 [0.35, 1.69]	3 studies · 655 participants	Low
Intervention NR Poor outcome Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage (2022) · Cochrane	RR 1.03 [0.94, 1.13]	5 studies · 2359 participants	High
Intervention NR All cause mortality Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage (2022) · Cochrane	RR 1.02 [0.9, 1.16]	11 studies · 2717 participants	High
Intervention NR Rebleeding Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage (2022) · Cochrane	RR 0.65 [0.47, 0.91]	11 studies · 2717 participants	Moderate
Intervention NR Delayed cerebral ischemia Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage (2022) · Cochrane	RR 1.27 [1, 1.62]	7 studies · 2484 participants	Moderate
Intervention NR Hydrocephalus Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage (2022) · Cochrane	RR 1.09 [0.99, 1.2]	6 studies · 1992 participants	High
Pharmaceutical interventions vs placebo Emotionalism (primary outcome) · emotionalism after stroke Pharmaceutical interventions for emotionalism after stroke (2022) · Cochrane	RR 0.26 [0.09, 0.77]	1 study · 19 participants	Very low
Pharmaceutical interventions vs placebo Emotionalism: mean scores at end of treatment ‐ Pathological Laughter and Crying Scale · emotionalism after stroke Pharmaceutical interventions for emotionalism after stroke (2022) · Cochrane	no estimate extracted	1 study · 28 participants	Low
Pharmaceutical interventions vs placebo Depression: Mean scores at end of treatment · emotionalism after stroke Pharmaceutical interventions for emotionalism after stroke (2022) · Cochrane	no estimate extracted	2 studies · 72 participants	Very low
Pharmaceutical interventions vs placebo Cognitive functioning: Mean scores at end of treatment · emotionalism after stroke Pharmaceutical interventions for emotionalism after stroke (2022) · Cochrane	no estimate extracted	1 study · 28 participants	Low
Pharmaceutical interventions vs placebo Activities of daily living: 1. Mean scores at end of treatment · emotionalism after stroke Pharmaceutical interventions for emotionalism after stroke (2022) · Cochrane	no estimate extracted	1 study · 28 participants	Low
Pharmaceutical interventions vs placebo Adverse events: 1. death: at end of treatment · emotionalism after stroke Pharmaceutical interventions for emotionalism after stroke (2022) · Cochrane	RR 0.59 [0.08, 4.5]	6 studies · 172 participants	Moderate
Occupational therapy vs usual care BADL (primary outcome) · adults with cognitive impairment after stroke Occupational therapy for cognitive impairment in stroke patients (2022) · Cochrane	no estimate extracted	1 participants	Ungraded
Occupational therapy vs usual care 5a. Visual attention overall (postintervention) · adults with cognitive impairment after stroke Occupational therapy for cognitive impairment in stroke patients (2022) · Cochrane	no estimate extracted	13 studies · 620 participants	Low