Nausea · participants with generalised epilepsy
Summary of findings: needle acupuncture plus valproate showed no clear difference in frequency of adverse effects ‐ nausea ( compared with valproate alone (low certainty).
1 finding from 1 review
Frequency of adverse effects ‐ sleepiness ( · participants with generalised epilepsy
Summary of findings: needle acupuncture plus valproate showed no clear difference in frequency of adverse effects ‐ sleepiness ( compared with valproate alone (low certainty).
1 finding from 1 review
Recurrent seizure at 6 months · children with febrile seizures
Continuous oral valproate showed no clear difference in recurrent seizure at 6 months compared with placebo or no treatment (low certainty).
1 finding from 1 review
Recurrent seizure at 12 months · children with febrile seizures
Continuous oral valproate showed no clear difference in recurrent seizure at 12 months compared with placebo or no treatment (low certainty).
1 finding from 1 review
Recurrent seizure at 18 months · children with febrile seizures
It is very uncertain whether continuous oral valproate changes recurrent seizure at 18 months compared with placebo or no treatment (very low certainty).
1 finding from 1 review
Recurrent seizure at 24 months · children with febrile seizures
Continuous oral valproate showed no clear difference in recurrent seizure at 24 months compared with placebo or no treatment (low certainty).
1 finding from 1 review
Recurrent seizure at 36 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 48 months · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recurrent seizure at 60 months or greater · children with febrile seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Sodium valproate · adults and children with generalised seizures*
1 finding from 1 review
Seizure freedom · absence seizures in children and adolescents
1 finding from 1 review
80% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents
It is very uncertain whether ethosuximide changes 80% or greater reduction in seizure frequency compared with valproate (very low certainty).
1 finding from 1 review
50% or greater reduction in seizure frequency · absence seizures in children and adolescents
1 finding from 1 review
Normalisation of the EEG ‐ not reported · absence seizures in children and adolescents
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Seizure freedom · absence seizures in children and adolescents
1 finding from 1 review
80% or greater reduction in seizure frequency ‐ not reported · absence seizures in children and adolescents
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
50% or greater reduction in seizure frequency · absence seizures in children and adolescents
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Normalisation of the EEG ‐ not reported · absence seizures in children and adolescents
It is very uncertain whether lamotrigine changes normalisation of the EEG compared with valproate (very low certainty).
1 finding from 1 review
Recurrent seizure at 6 months · children with febrile seizures
It is very uncertain whether intermittent rectal diazepam changes recurrent seizure at 6 months compared with intermittent rectal valproate (very low certainty).
1 finding from 1 review
Recurrent seizure at 12 months · children with febrile seizures
Intermittent rectal diazepam showed no clear difference in recurrent seizure at 12 months compared with intermittent rectal valproate (low certainty).
1 finding from 1 review